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Merck

L135

L-741,626

≥98% (HPLC)

Synonyme(s) :

(±)-3-[4-(4-Chlorophenyl)-4-hydroxypiperidinyl]methylindole

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A propos de cet article

Formule empirique (notation de Hill) :
C20H21ClN2O
Numéro CAS:
81226-60-0
Poids moléculaire :
340.85
NACRES:
NA.77
PubChem Substance ID:
24278529
UNSPSC Code:
12352200
MDL number:
MFCD00953632
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Principaux documents

Voir toute la documentation
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InChI

1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2

SMILES string

OC1(CCN(CC1)Cc2c[nH]c3ccccc23)c4ccc(Cl)cc4

InChI key

LLBLNMUONVVVPG-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥20 mg/mL, ethanol: 24 mg/mL, H2O: insoluble

storage temp.

room temp

Quality Level

100

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815)

Application

L-741,626 has been used as selective dopamine (D2) receptor antagonist to study its effects on the uptake of dopamine in human embryonic kidney 293 (HEK293) cells. It has also been used as a D2 receptor antagonist to study its effects on thyrotropin-releasing hormone (TRH) induced prolactin release.

Biochem/physiol Actions

L-741,626 is a selective dopamine (D2) receptor antagonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000086786
0000071707
0000071706
0000027392
0000027393

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

B J Bowery et al.
British journal of pharmacology, 119(7), 1491-1497 (1996-12-01)
1. The ability of PD 128907 to activate dopamine receptors in the ventral tegmental area, substantia nigra pars compacta, and striatum was investigated by use of in vitro electrophysiological recording and fast cyclic voltammetry. The affinity of a novel D2
Florence Loiseau et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 19(1), 23-33 (2008-09-17)
Though D(3) receptor antagonists can enhance cognitive function, their sites of action remain unexplored. This issue was addressed employing a model of social recognition in rats, and the actions of D(3) antagonists were compared to D(1) agonists that likewise possess
Masaki Nakano et al.
General and comparative endocrinology, 168(2), 287-292 (2010-06-18)
Dopamine receptors in mammals are known to consist of two D1-like receptors (D1 and D5) and three D2-like receptors (D2, D3 and D4). The aim of this study was to determine the dopamine receptor subtype that mediates the inhibitory action
Alexander Gont et al.
Oncotarget, 8(5), 8559-8573 (2017-01-05)
A defining feature of the brain cancer glioblastoma is its highly invasive nature. When glioblastoma cells are isolated from patients using serum free conditions, they accurately recapitulate this invasive behaviour in animal models. The Rac subclass of Rho GTPases has
Wen-Ling Dai et al.
Scientific reports, 6, 38746-38746 (2016-12-23)
Tolerance induced by morphine remains a major unresolved problem and significantly limits its clinical use. Recent evidences have indicated that dopamine D2 receptor (D2DR) is likely to be involved in morphine-induced antinociceptive tolerance. However, its exact effect and molecular mechanism
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