L7527
Lipoprotein, very low density from human plasma
≥95% (SDS-PAGE), solution
Synonyme(s) :
Pre-β-lipoprotein, VLDL, Very low density lipoprotein
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VLDL (Very low density lipoprotein) may be used to study the mechanisms and effects of very low density receptors (VLDLR). VLDL is used as a potential source of fatty acids that support cardiac energy metabolism. VLDL is often studied to differentiate its effects from those of chylomicrons.
Inhibits DNA synthesis in lymphocytes activated by the nonspecific mitogen concanavalin A (Con A).
Physical form
Solution in 150 mM NaCl and 0.01% EDTA, pH 7.4
Other Notes
View more information on lipoprotein function and lipid transport at www.sigma-aldrich.com/enzymeexplorer
Classe de stockage
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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M C Sampedro et al.
Biochemical and biophysical research communications, 285(2), 393-399 (2001-07-11)
Human very-low-density lipoprotein (VLDL) inhibits DNA synthesis in lymphocytes activated by the nonspecific mitogen concanavalin A (Con A). We studied the effects of VLDL on lymphocyte activation (IL-2 receptor expression), cell cycle progression, and production of IL-2 and of IL-4
Samata Tiwari et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(5), 1079-1086 (2012-04-21)
Steady increase in the incidence of atherosclerosis is becoming a major concern not only in the United States but also in other countries. One of the major risk factors for the development of atherosclerosis is high concentrations of plasma low-density
Gwang-Woong Go et al.
The Yale journal of biology and medicine, 85(1), 19-28 (2012-03-31)
The LDLR family of proteins is involved in lipoproteins trafficking. While the role of LDLR in cardiovascular disease has been widely studied, only recently the role of other members of the LDLR proteins in lipoprotein homeostasis and atherosclerosis has emerged.