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M5273

Monensin sodium salt

Name: Monensin sodium salt
Brand: SIGMA

90-95% (TLC), Sodium ionophore

Synonyme(s) :

Monensin A sodium salt

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A propos de cet article

Formule empirique (notation de Hill) :

C₃₆H₆₁NaO₁₁

Numéro CAS:

22373-78-0

Poids moléculaire :

692.85

NACRES:

NA.77

PubChem Substance ID:

24896992

UNSPSC Code:

12352200

EC Number:

244-941-7

MDL number:

MFCD00077826

Beilstein/REAXYS Number:

4122200

Assay:

90-95% (TLC)

Quality level:

200

Service technique

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Propriétés

Nom du produit

Monensin sodium salt, 90-95% (TLC)

Quality Level

200

assay

90-95% (TLC)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, fungi, parasites, viruses

mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

[H][C@]1([C@@]2(CC)O[C@]([C@@]3(C)OC4(C[C@H](O)[C@@H](C)[C@@]([H])([C@@H](C)[C@@H](OC)[C@@H](C([O-])=O)C)O4)CC3)([H])CC2)[C@@H](C)C[C@]([H])([C@@]5([H])O[C@@](O)(CO)[C@H](C)C[C@@H]5C)O1.[Na+]

InChI

1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35?,36-;/m0./s1

InChI key

XOIQMTLWECTKJL-BEMBKCOJSA-M

Description

General description

Chemical structure: polyether

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis in poultry production.

Application

Monensin sodium salt has been used:

for the intracellular staining of cytokines
to study its effects on the regulation of nuclear factor-κ B (NF-κB ) activation
as a positive control to study its effects on in vitro rumen fermentation

Biochem/physiol Actions

Na⁺ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.