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Merck

M8644

Anti-Mouse IgM (μ-chain specific) antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Goat anti-mouse IgM

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46
MDL number:

Nom du produit

Anti-Mouse IgM (μ-chain specific) antibody produced in goat, affinity isolated antibody, lyophilized powder

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

form

lyophilized powder

technique(s)

indirect ELISA: suitable

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

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Catégories apparentées

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Chromatin immunoprecipitation (1 paper)
Enzyme-linked immunosorbent assay (1 paper)
Goat polyclonal anti-Mouse IgM (μ-chain specific) antibody may be used to identify and quantitate the level of mouse IgM in vitro and in human serum or other biological fluids by immunochemical or immunohistological techniques.

Biochem/physiol Actions

Goat polyclonal anti-Mouse IgM (μ-chain specific) antibody reacts with the m-chain of mouse IgM. It is s specific for mouse IgM when tested against purified mouse IgA, IgG1, IgG2a, IgG2b, IgG3, and IgM, myeloma proteins.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Mouse serum-derived IgM may be used as a reference antigen, standard, blocking agent, or coating protein in a variety of immunoassays including ELISA, dot immunobinding, Western immunoblotting, immunodiffusion, and immunoelectrophoresis. Other applications include starting materials for the preparation of immunogens and solid phase immunoadsorbents.
Immunoglobulin M (IgM) antibodies appear early in the course of infections. IgM antibodies are responsible for agglutination of red blood cells in mis-matched blood transfusions. The level of IgM may vary with the status of disease or infection.

Physical form

Lyophilized from 0.01 M sodium phosphate, 0.015 M sodium chloride, pH 7.2

Preparation Note

Reconstitute with 0.135 M sodium chloride.

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Classe de stockage

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Consulter la Bibliothèque de documents

Andrew Elvington et al.
Journal of immunology (Baltimore, Md. : 1950), 189(9), 4640-4647 (2012-10-03)
There is mounting evidence indicating an important role for complement in the pathogenesis of cerebral ischemia-reperfusion injury, or ischemic stroke. The role of the alternative complement pathway in ischemic stroke has not been investigated, and there is conflicting data on
Yasmine Zouggari et al.
Nature medicine, 19(10), 1273-1280 (2013-09-17)
Acute myocardial infarction is a severe ischemic disease responsible for heart failure and sudden death. Here, we show that after acute myocardial infarction in mice, mature B lymphocytes selectively produce Ccl7 and induce Ly6C(hi) monocyte mobilization and recruitment to the
Louis Scheurer et al.
Life science alliance, 4(11) (2021-08-27)
General consensus states that immunoglobulins are exclusively expressed by B lymphocytes to form the first line of defense against common pathogens. Here, we provide compelling evidence for the expression of two heavy chain immunoglobulin genes in subpopulations of neurons in
Dimitrios Tsiantoulas et al.
Scientific reports, 7(1), 3540-3540 (2017-06-16)
Mice lacking secreted IgM (sIgM -/-) antibodies display abnormal splenic B cell development, which results in increased marginal zone and decreased follicular B cell numbers. However, the mechanism by which sIgM exhibit this effect is unknown. Here, we demonstrate that
Daniel Neumeier et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(18), e2113766119-e2113766119 (2022-04-30)
The capacity of humoral B cell-mediated immunity to effectively respond to and protect against pathogenic infections is largely driven by the presence of a diverse repertoire of polyclonal antibodies in the serum, which are produced by plasma cells (PCs). Recent

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