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Merck

M8750

(+)-Methamphetamine hydrochloride

Synonyme(s) :

d-Desoxyephedrine hydrochloride, d-N,α-Dimethylphenethylamine hydrochloride, Methylamphetamine hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C10H15N · HCl
Numéro CAS:
51-57-0
Poids moléculaire :
185.69
NACRES:
NA.77
PubChem Substance ID:
24897282
UNSPSC Code:
12352116
EC Number:
200-106-9
MDL number:
MFCD00056130

Principaux documents

Voir toute la documentation
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InChI key

TWXDDNPPQUTEOV-FVGYRXGTSA-N

InChI

1S/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H/t9-;/m0./s1

SMILES string

Cl[H].CN[C@@H](C)Cc1ccccc1

Quality Level

200

Gene Information

human ... SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)

drug control

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

solubility

H2O: soluble, ethanol: soluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

originator

Teva

Catégories apparentées

Biochem/physiol Actions

Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.

Features and Benefits

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300,H336

Hazard Classifications

Acute Tox. 2 Oral - STOT SE 3

target_organs

Central nervous system

Classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number
SLCL6640
SLCC8107
SLBS1221V
SLBT1207
SLBV9808

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Kaveh Shahveisi et al.
Pharmacology, biochemistry, and behavior, 185, 172759-172759 (2019-08-16)
Susceptibility to interference can be a result of memory retrieval and reconsolidation. Given the fact that addiction develops through the neural mechanisms of learning and memory, it would not be surprising that a consolidated drug reward memory may also be
G J Rivière et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1220-1226 (1999-11-24)
The purpose of these studies was to better understand the behavioral effects and pharmacokinetics of an i.v. bolus dose of (+)-methamphetamine [(+)-METH] in a rat model of (+)-METH abuse. We characterized the behavioral effects after increasing (+)-METH doses (0.1, 0.3
Leila Rezaeian et al.
Iranian journal of basic medical sciences, 23(11), 1480-1488 (2020-11-26)
This research aimed at evaluating the effect of berberine hydrochloride on anxiety-related behaviors induced by methamphetamine (METH) in rats, assessing relapse and neuroprotective effects. 27 male Wistar rats were randomly assigned into groups of Control, METH-withdrawal (METH addiction and subsequent
Noémie Cresto et al.
International journal of molecular sciences, 22(13) (2021-07-03)
Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson's disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understood. We previously showed that the
Arkadiusz Liśkiewicz et al.
Brain, behavior, and immunity, 80, 247-254 (2019-03-20)
Methamphetamine (METH) abusers are prone to develop a variety of comorbidities, including cognitive disabilities, and the immunological responses have been recognized as an important component involved in the toxicity of this drug. Cytokines are among the key mediators between systemic
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