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Merck

M9292

Memantine hydrochloride

≥98% (GC), powder, NMDA glutamate receptor antagonist

Synonyme(s) :

3,5-Dimethyl-1-adamantanamine hydrochloride, 3,5-Dimethylamantadine hydrochloride, 3,5-Dimethyltricyclo[3.3.1.13,7]decan-1-amine hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C12H21N · HCl
Numéro CAS:
41100-52-1
Poids moléculaire :
215.76
NACRES:
NA.77
PubChem Substance ID:
24277990
UNSPSC Code:
12352200
EC Number:
255-219-6
MDL number:
MFCD00214336

Principaux documents

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Nom du produit

Memantine hydrochloride, ≥98% (GC)

Quality Level

100

InChI key

LDDHMLJTFXJGPI-VXMZOEJHSA-N

InChI

1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H/t9-,10+,11-,12-;

SMILES string

Cl.C[C@]12CC3C[C@](C)(C1)CC(N)(C3)C2

assay

≥98% (GC)

form

powder

originator

Forest Labs

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

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Catégories apparentées

Application

Memantine hydrochloride has been used:
  • as a media supplement to serve as a control to study the neuroprotective effects of erythropoietin in N-methyl-D-aspartate receptor-induced toxicity
  • to intraperitoneally inject experimental animal to study its effect on traumatic injury
  • as a test compound to determine the dynamic range and selectivity of retinal pigment epithelium tissue penetration

Biochem/physiol Actions

Low-affinity NMDA glutamate receptor antagonist; stimulates dopamine release.
Memantine is effective against Alzheimer′s disease and Parkinson′s disease. It is also useful in treating epilepsy, motor neurone disease and trauma.

Features and Benefits

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
WXBF7311V
0000173273
0000173273
WXBD8600V
MKCQ2227

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Anton N Shuvaev et al.
International journal of molecular sciences, 22(15) (2021-08-08)
Spinocerebellar ataxias are a family of fatal inherited diseases affecting the brain. Although specific mutated proteins are different, they may have a common pathogenetic mechanism, such as insufficient glutamate clearance. This function fails in reactive glia, leading to excitotoxicity and
M Weller et al.
Brain research, 613(1), 143-148 (1993-06-04)
Effects of amantadine and memantine on NMDA receptor-mediated glutamate toxicity were studied in cultured cerebellar, cortical and mesencephalic neurons. Both drugs protected cerebellar and cortical neurons against glutamate toxicity, memantine being consistently more effective than amantadine but less effective than
C G Parsons et al.
Neuropharmacology, 32(12), 1337-1350 (1993-12-01)
Memantine (1-amino-3,5-dimethyladamantan) was tested as an antagonist of N-methyl-D-aspartate (NMDA) receptors on cultured superior collicular and hippocampal neurones using the patch clamp technique and its actions were compared to those of Mg2+ ions, ketamine, dextrorphan, dextromethorphan, phencyclidine and dizocilpine (MK-801).
Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine
Kelestemur T, et al.
Neuroscience Letters, 612(1), 92-97 (2016)
Anton N Shuvaev et al.
Brain sciences, 12(4) (2022-04-22)
Memantine is an FDA approved drug for the treatment of Alzheimer's disease. It reduces neurodegeneration in the hippocampus and cerebral cortex through the inhibition of extrasynaptic NMDA receptors in patients and mouse models. Potentially, it could prevent neurodegeneration in other
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Contenu apparenté

Product Information Sheet - M9292

Product Information Sheet

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