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N129

Naloxone methiodide

Name: Naloxone methiodide
Brand: SIGMA

≥98% (HPLC), opioid receptor inhibitor, solid

Synonyme(s) :

(5α,17R)-4,5-Epoxy-3,14-dihydroxy-17-methyl-6-oxo-17-(2-propenyl)-morphinanium iodide, N-Methylnaloxonium iodide

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₀H₂₄INO₄

Numéro CAS:

93302-47-7

Poids moléculaire :

469.31

UNSPSC Code:

12352200

PubChem Substance ID:

24897480

NACRES:

NA.77

MDL number:

MFCD00078592

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Propriétés

Nom du produit

Naloxone methiodide, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to tan

solubility

H₂O: >10 mg/mL

storage temp.

2-8°C

SMILES string

[I-].[H][C@]12Oc3c(O)ccc4C[C@@H]5[C@](O)(CCC1=O)[C@@]2(CC[N@+]5(C)CC=C)c34

InChI

1S/C20H23NO4.HI/c1-3-9-21(2)10-8-19-16-12-4-5-13(22)17(16)25-18(19)14(23)6-7-20(19,24)15(21)11-12;/h3-5,15,18,24H,1,6-11H2,2H3;1H/t15-,18+,19+,20-,21?;/m1./s1

InChI key

ICONPJDAXITIPI-UXYWFNEESA-N

Description

Application

Naloxone methiodide has been used as inhibitor of opioid receptor in fish and mice. Naloxone methiodide has been used to block opioid neurotransmission.

Biochem/physiol Actions

Naloxone methiodide has low affinity for opioid receptors than naloxone. Administration of naloxone inhibits opioid receptor and opioid-induced respiratory depression.

Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. It does not cross the blood-brain barrier.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation.

Helvira Melo et al.

Scientific reports, 8(1), 15551-15551 (2018-10-21)

Opioids remain the gold standard for the treatment of moderate to severe pain. However, their analgesic properties come with important side effects, including pruritus, which occurs frequently after systemic or neuraxial administration. Although part of the opioid-induced itch is mediated

Delta opioid receptors are essential to the antiallodynic action of Β2-mimetics in a model of neuropathic pain.

Mélanie Kremer et al.

Molecular pain, 16, 1744806920912931-1744806920912931 (2020-03-27)

Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for mu, delta, and kappa opioid receptors in mouse brain homogenates

Lewanowitsch Tanya and Irvine RJ

Brain Research, 964(2), 302 -3305 (2003)

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