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Merck

O6379

Oxytocin acetate salt hydrate

synthetic (organic), ≥97% (HPLC), vasopressin receptor partial agonist, powder

Synonyme(s) :

α-Hypophamine

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A propos de cet article

Formule empirique (notation de Hill) :
C43H66N12O12S2
Numéro CAS:
50-56-6
Poids moléculaire :
1007.19
NACRES:
NA.32
PubChem Substance ID:
24898033
UNSPSC Code:
51111800
EC Number:
200-048-4
MDL number:
MFCD00133730
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥97% (HPLC)

Principaux documents

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Nom du produit

Oxytocin acetate salt hydrate, ≥97% (HPLC)

form

powder

InChI key

XNOPRXBHLZRZKH-UHFFFAOYSA-N

InChI

1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)

SMILES string

CCC(C)C1NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC1=O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(N)=O

biological source

synthetic (organic)

sterility

non-sterile

assay

≥97% (HPLC)

solubility

water: 10 mg/mL, clear, colorless

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Gene Information

human ... OXT(5020)

Catégories apparentées

Application

Oxytocin acetate salt hydrate has been used in cell proliferation assay and is used in experiments to study the effect of oxytocin in the prelimbic (PL) region of the medial prefrontal cortex (mPFC) on anxiety. It is used as a marker in receptor autoradiography to assess nonspecific tissue binding in the periphery of the neonatal mouse.

Biochem/physiol Actions

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders, and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).
Stimulates uterine contraction and lactation; increases Na+ excretion; stimulates myometrial GTPase and phospholipase C.

General description

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns, where first exon codes for hormone OXT while other exon codes for neurophysin I.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000497913
0000497913
0000496155
0000496155
0000424289

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Consulter la Bibliothèque de documents

Dara K Shahrokh et al.
Endocrinology, 151(5), 2276-2286 (2010-03-17)
Variations in maternal behavior among lactating rats associate with differences in estrogen-oxytocin interactions in the medial preoptic area (mPOA) and in dopamine levels in the nucleus accumbens (nAcc). Thus, stable, individual differences in pup licking/grooming (LG) are abolished by oxytocin
Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat.
Shahrokh DK
Endocrinology, 151(5), 2276-2286 (2010)
Paloma P Maldonado et al.
Current biology : CB, 31(2), 322-333 (2020-11-07)
Spontaneous network activity shapes emerging neuronal circuits during early brain development prior to sensory perception. However, how neuromodulation influences this activity is not fully understood. Here, we report that the neuromodulator oxytocin differentially shapes spontaneous activity patterns across sensory cortices.
Oxytocin receptor binding sites in the periphery of the neonatal mouse.
Greenwood MA
PLoS ONE, 12(2), e0172904-e0172904 (2017)
Sara Sabihi et al.
Psychoneuroendocrinology, 45, 31-42 (2014-05-23)
The neuropeptide oxytocin (OT) is anxiolytic in rodents and humans. However, the specific brain regions where OT acts to regulate anxiety requires further investigation. The medial prefrontal cortex (mPFC) has been shown to play a role in the modulation of
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