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Merck

O8264

Anti-Orai1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

CRACM1, Calcium release-activated calcium channel protein 1, TMEM142A, Transmembrane protein 142A

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A propos de cet article

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
62

Principaux documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~35 kDa (non-glycosylated), antigen ~50 kDa (glycosylated)

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

western blot: 1-2 μg/mL using whole extract of human HEK-293T cells expressing ORAI1

UniProt accession no.

Q96D31

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... ORAI1(84876)
mouse ... Orai1(109305)

General description

ORAI calcium release-activated calcium modulator 1 (ORAI1) is the pore-forming subunit of the Ca2+ release-activated (CRAC) channel. The protein possesses four predicted transmembrane domains and intracellular amino and carboxyl-terminal domains. The ORAI1 gene is localized on human chromosome 12q24.31.

Immunogen

synthetic peptide corresponding to amino acids 288-301 of human ORAI1, conjugated to KLH. The corresponding sequence differs by 2 amino acids in rat and mouse.

Application

Anti-ORAI1 antibody produced in rabbit has been used in immunohistochemistry and Western blotting.

Biochem/physiol Actions

ORAI calcium release-activated calcium modulator 1 (ORAI1) modulates Ca2+ entry into cells. The channel is activated by stromal interaction molecule-1 (STIM-1). Mutation in the gene encoding the protein has been linked to late-onset tubular aggregate myopathy and congenital miosis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Classe de stockage

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000493498
0000493498
0000489314
0000489314
0000346731

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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Antibody-Mediated Targeting of the Orai1 Calcium Channel Inhibits T Cell Function
Jennifer H. Cox
PLoS ONE (2013)
Calcium Influx of Mast Cells Is Inhibited by Aptamers Targeting the First Extracellular Domain of Orai1
Renshan Sun
PLoS ONE (2016)
Yi-Chun Yeh et al.
Molecular and cellular biology, 35(8), 1341-1349 (2015-02-04)
In eukaryotic cells, calcium entry across the cell surface activates nuclear gene expression, a process critically important for cell growth and differentiation, learning, and memory and immune cell functions. In immune cells, calcium entry occurs through store-operated Ca(2+) release-activated Ca(2+)
Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel.
Yen M
Biophysical Journal (2016)
Jennifer H Cox et al.
PloS one, 8(12), e82944-e82944 (2014-01-01)
Despite the attractiveness of ion channels as therapeutic targets, there are no examples of monoclonal antibodies directed against ion channels in clinical development. Antibody-mediated inhibition of ion channels could offer a directed, specific therapeutic approach. To investigate the potential of
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Contenu apparenté

Data Sheet - O8264

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