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Merck

O9387

Oxatomide

≥99%

Synonyme(s) :

1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one

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A propos de cet article

Formule empirique (notation de Hill) :
C27H30N4O
Numéro CAS:
60607-34-3
Poids moléculaire :
426.55
NACRES:
NA.77
PubChem Substance ID:
24278615
UNSPSC Code:
51111800
EC Number:
262-320-9
MDL number:
MFCD00211147

Principaux documents

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InChI

1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)

InChI key

BAINIUMDFURPJM-UHFFFAOYSA-N

SMILES string

O=C1Nc2ccccc2N1CCCN3CCN(CC3)C(c4ccccc4)c5ccccc5

assay

≥99%

form

powder

color

white

solubility

DMSO: soluble, ethanol: soluble

originator

Johnson & Johnson

Quality Level

100

Gene Information

human ... DRD3(1814)

General description

Oxatomide, a histamine H1-receptor antagonist, is bound at high levels to plasma proteins in human blood.

Biochem/physiol Actions

Oxatomide is an anti-allergy compound. It suppresses platelet activating factor (PAF)-induced bronchoconstriction and inhibits leukotriene production.
Oxatomide, found in several antihistamines, can suppress mast cell degranulation. It can be used as an alternative to individuals with allergic rhinitis who do not or poorly respond to more established antihistamines. Oxatomide exhibits both antihistamine and anti-inflammatory properties. It exhibits therapeutic effects against asthma and vulvar lichen sclerosus.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

wgk

WGK 3

Classe de stockage

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
MKCT6989
MKCT8869
MKCR1623
MKCR7151
MKCP1201

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Consulter la Bibliothèque de documents

Mariko Domae et al.
The Journal of allergy and clinical immunology, 111(3), 567-572 (2003-03-19)
Eosinophils accumulated in sites of allergic inflammation are thought to play a crucial role in the pathogenesis of allergic disorders including asthma, allergic rhinitis, and atopic dermatitis, and tissue eosinophilia is attributable to increased eosinophil survival or decreased eosinophil apoptosis.
H Kimata
European journal of clinical investigation, 33(6), 513-517 (2003-06-11)
Playing video games causes physical and psychological stress, including increased heart rate and blood pressure and aggression-related feelings. Use of mobile phones is very popular in Japan, and frequent ringing is a common and intrusive part of Japanese life. Atopic
Hiroyuki Mizuguchi et al.
Pharmaceutics, 12(6) (2020-06-12)
H1-antihistamines antagonize histamine and prevent it from binding to the histamine H1 receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activity. Bilastine is a non-sedative
D M Richards et al.
Drugs, 27(3), 210-231 (1984-03-01)
Oxatomide is an orally active H1-histamine receptor antagonist which, as appears to occur with some other antihistamines, also inhibits mast cell degranulation. Oxatomide has demonstrated response rates similar to those with other more established members of its drug class in
Yong-Soo Park et al.
The Laryngoscope, 116(9), 1642-1646 (2006-09-07)
Inflammatory mediators (IMs) play a major role in the production of middle ear effusion (MEE). Tumor necrosis factor (TNF)-alpha and leukotrienes (LTs) appear to be important in the pathogenesis of otitis media with effusion (OME). The purpose of this study
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