O9387
Oxatomide
≥99%
Synonyme(s) :
1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one
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A propos de cet article
Formule empirique (notation de Hill) :
C27H30N4O
Numéro CAS:
Poids moléculaire :
426.55
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
262-320-9
MDL number:
Service technique
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Laissez-nous vous aiderQuality Level
assay
≥99%
form
powder
color
white
solubility
DMSO: soluble, ethanol: soluble
originator
Johnson & Johnson
SMILES string
O=C1Nc2ccccc2N1CCCN3CCN(CC3)C(c4ccccc4)c5ccccc5
InChI
1S/C27H30N4O/c32-27-28-24-14-7-8-15-25(24)31(27)17-9-16-29-18-20-30(21-19-29)26(22-10-3-1-4-11-22)23-12-5-2-6-13-23/h1-8,10-15,26H,9,16-21H2,(H,28,32)
InChI key
BAINIUMDFURPJM-UHFFFAOYSA-N
Gene Information
human ... DRD3(1814)
General description
Oxatomide, a histamine H1-receptor antagonist, is bound at high levels to plasma proteins in human blood.
Biochem/physiol Actions
Oxatomide is an anti-allergy compound. It suppresses platelet activating factor (PAF)-induced bronchoconstriction and inhibits leukotriene production.
Oxatomide, found in several antihistamines, can suppress mast cell degranulation. It can be used as an alternative to individuals with allergic rhinitis who do not or poorly respond to more established antihistamines. Oxatomide exhibits both antihistamine and anti-inflammatory properties. It exhibits therapeutic effects against asthma and vulvar lichen sclerosus.
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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D M Richards et al.
Drugs, 27(3), 210-231 (1984-03-01)
Oxatomide is an orally active H1-histamine receptor antagonist which, as appears to occur with some other antihistamines, also inhibits mast cell degranulation. Oxatomide has demonstrated response rates similar to those with other more established members of its drug class in
M Origoni et al.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 55(3), 259-264 (1996-12-01)
The treatment of vulvar lichen sclerosus has greatly improved in recent years, with the introduction of new pharmacological approaches and reconsideration of the traditional ones. Oxatomide is a molecule with both antihistamine and inhibiting activities for the inflammatory response, which
Yong-Soo Park et al.
The Laryngoscope, 116(9), 1642-1646 (2006-09-07)
Inflammatory mediators (IMs) play a major role in the production of middle ear effusion (MEE). Tumor necrosis factor (TNF)-alpha and leukotrienes (LTs) appear to be important in the pathogenesis of otitis media with effusion (OME). The purpose of this study