P0042
PP2
≥98% (HPLC), Src-family tyrosine kinase inhibitor, powder
Synonyme(s) :
4-Amino-3-(4-chlorophenyl)-1-(t-butyl)-1H-pyrazolo[3,4-d]pyrimidine, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine, AG 1879
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A propos de cet article
Formule empirique (notation de Hill) :
C15H16ClN5
Numéro CAS:
Poids moléculaire :
301.77
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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PP2, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c3c(N)ncnc13
InChI
1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChI key
PBBRWFOVCUAONR-UHFFFAOYSA-N
Application
PP2 has been used:
- to analyze the effects of Src/focal adhesion kinase (FAK) signaling on IQ domain GTPase-activating protein 1 (IQGAP1)-mediated anoikis resistance
- for Src inhibition to study its effect on epidermal growth factor receptor (EGFR) and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation in non-small cell lung cancer (NSCLC) cells
- for pharmacological inhibition of SRC in MDA-MB-231 breast cancer cells
Biochem/physiol Actions
PP2 is a selective inhibitor of Src-family tyrosine kinases of non-receptor tyrosine kinases (nRTK). It shows >10,000-fold selectivity over Zeta-chain-associated protein kinase 70 (ZAP-70) and Janus kinase 2 (JAK2). PP2 effectively reduces cervical cancer proliferation in vitro and in vivo.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
Not applicable
flash_point_c
Not applicable
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