Anti-Potassium Channel K_v11.1 Extracellular antibody produced in rabbit

The K⁺ channel family has been sub-grouped in to 2 TM, 4 TM and 6 TM K⁺ channels based on the number of transmembrane domains. The voltage-gated Potassium or K_v channels belong to the 6 TM K⁺ channel family that also include other sub-types such as the hERG, KCNQ, and EAG channels. K_v11.1 belongs to the EAG family and facilitates the repolarization of normal action potential in heart muscles. Genetic alterations in K_v11.1 can cause heart disorders such as long QT syndrome, sudden cardiac death and arhythmias. K_v11.1 also regulates cell growth and hence may be studied as a target for cancer treatment. Anti-Potassium channel K_v11.1 extracellular antibodies are specific to K_v11.1.

peptide AFLLKETEEGPPATEC corresponding to residues 430-445 of human K_V11.1. This sequence has 11/16 residues identical in mouse and rat and has 15/16 residues identical in rabbit and dog.

Anti-Potassium channel K_v11.1 extracellular antibodies may be used in immunofluorescence microscopy . It may also be used for the detection of K_v11.1 by techniques such as immunocytochemistry, flow cytometry using live intact K562 (human chronic myelogenous leukemia) cells and western blotting.

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

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