P4651
Promethazine hydrochloride
histamine receptor antagonist, powder
Synonyme(s) :
10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride
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A propos de cet article
Formule empirique (notation de Hill) :
C17H20N2S · HCl
Numéro CAS:
Poids moléculaire :
320.88
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-375-2
MDL number:
Beilstein/REAXYS Number:
4166397
Form:
powder
Service technique
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Promethazine hydrochloride,
form
powder
originator
Wyeth
storage temp.
2-8°C
SMILES string
Cl[H].CC(CN1c2ccccc2Sc3ccccc13)N(C)C
InChI
1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
InChI key
XXPDBLUZJRXNNZ-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269)
Biochem/physiol Actions
H1 histamine receptor antagonist; CNS depressant; anticholinergic.
Features and Benefits
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Physical form
Appearance: White or faint yellow, odorless, Crystalline powder, slowly oxidizes and acquires a blue color, on prolonged exposure to air.
Other Notes
Solubility: Freely soluble in water, in hot dehydrated alcohol and in Chloroform. Practically insoluble in ether, in acetone and in ethyl acetate.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1
Classe de stockage
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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A B Wright et al.
Ultrasound in medicine & biology, 25(2), 241-247 (1999-05-13)
This sonographic study was aimed at examining the effect of sedation with promethazine (1.5 mg x kg(-1)), on gastroduodenal function in neonatal piglets. On 3 consecutive days, observations of gastroduodenal motility during the first 3 postprandial h were made in
Z Li et al.
Neuroscience, 70(1), 145-158 (1996-01-01)
Ionic mechanisms responsible for histamine-induced prolonged depolarization in supraoptic nucleus neurons were investigated using whole-cell patch recordings in horizontally prepared brain slices from adult male rats. Bath application of histamine (1-10 microM) in control medium induced membrane depolarization in nine
Frank Fasbender et al.
Archives of toxicology, 94(2), 439-448 (2020-02-16)
Drug-induced liver injury (DILI) represents one of the major causes why drugs have to be withdrawn from the market. In this study, we describe a new interaction between drug-exposed hepatocytes and natural killer (NK) cells. In a previous genome-wide expression