P4670
Propafenone hydrochloride
Synonyme(s) :
1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride
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A propos de cet article
Formule empirique (notation de Hill) :
C21H27NO3 · HCl
Numéro CAS:
Poids moléculaire :
377.90
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
251-867-9
MDL number:
Form:
powder
Quality level:
Service technique
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powder
Quality Level
originator
Abbott
storage temp.
2-8°C
SMILES string
Cl[H].CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2
InChI
1S/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
InChI key
XWIHRGFIPXWGEF-UHFFFAOYSA-N
Gene Information
General description
Propafenone hydrochloride is a calcium antagonist. It functions as a Na+ and K+ channel blocker. It might be used to treat patients with systemic hypertension. Propafenone hydrochloride is associated with bradycardia and bronchospasms. It is metabolized in the liver. Propafenone hydrochloride is used to treat ventricular arrhythmias.
Application
Propafenone hydrochloride has been used in the isolation of cardiomyocytes.
Biochem/physiol Actions
Blocks hKv1.5 and ATP-sensitive K+ channels; class 1C antiarrhythmic agent that is also an antagonist at β adrenergic receptors.
Features and Benefits
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
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The multiple modes of action of propafenone
Dukes ID and Williams EMV
European Heart Journal, 5(2), 115-125 (1984)
Propafenone hepatotoxicity: report of a new case and review of the literature
Younan LB, et al.
Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association, 19(5), 235-235 (2013)
Lori D Bash et al.
Cardiovascular drugs and therapy, 26(2), 167-179 (2012-03-16)
Rate and rhythm control are two well established treatment objectives for atrial fibrillation (AF) patients. While symptom reduction is a primary treatment goal, therapeutic practice related to cardioversion varies by region and patient, with several precautions associated with the use