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P6149

Progesterone

Name: Progesterone
Brand: SIGMA

γ-irradiated, BioXtra, suitable for cell culture

Synonyme(s) :

4-Pregnene-3,20-dione

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₁H₃₀O₂

Numéro CAS:

57-83-0

Poids moléculaire :

314.46

UNSPSC Code:

12352209

NACRES:

NA.77

PubChem Substance ID:

24898649

EC Number:

200-350-6

Beilstein/REAXYS Number:

1915950

MDL number:

MFCD00003658

Biological source:

synthetic (organic)

Form:

powder

Assay:

≥99%

Service technique

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Propriétés

biological source

synthetic (organic)

Quality Level

200

description

synthesized from materials derived from plant source

sterility

γ-irradiated

product line

BioXtra

assay

≥99%

form

powder

potency

0.1-20 ng/mL

technique(s)

cell culture | mammalian: suitable

mp

128-132 °C (lit.)

solubility

chloroform: 50 mg/mL, clear, colorless to light yellow

shipped in

ambient

storage temp.

room temp

SMILES string

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

Gene Information

human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

Description

Application

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Induit la maturation et l′activité secrétoire de l′endothélium utérin ; supprime l′ovulation.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Preparation Note

To prepare 20 μg/ml stock solution, add 1 ml absolute ethanol, gently swirl to dissolve, add 49 ml sterile medium.

Other Notes

Steroid hormone produced by the corpus luteum.

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pictograms

GHS08

signalword

Danger

hcodes

H351,H360FD,H362

pcodes

P202 - P260 - P263 - P264 - P280 - P308 + P313

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number

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Hippocampal volume and functional connectivity changes during the female menstrual cycle.

Nina Lisofsky et al.

NeuroImage, 118, 154-162 (2015-06-10)

Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle.

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight.

Cathrin Brisken

Nature reviews. Cancer, 13(6), 385-396 (2013-05-25)

Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase

HIV protease inhibitor use during pregnancy is associated with decreased progesterone levels, suggesting a potential mechanism contributing to fetal growth restriction.

Eszter Papp et al.

The Journal of infectious diseases, 211(1), 10-18 (2014-07-18)

Protease inhibitor (PI)-based combination antiretroviral therapy (cART) is administered during pregnancy to prevent perinatal human immunodeficiency virus (HIV) transmission. However, PI use has been associated with adverse birth outcomes, including preterm delivery and small-for-gestational-age (SGA) births. The mechanisms underlying these

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