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P7791

Prazosin hydrochloride

Name: Prazosin hydrochloride
Brand: SIGMA

≥99.0% (HPLC), powder, α1-adrenoceptor antagonist

Synonyme(s) :

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :

C₁₉H₂₁N₅O₄ · HCl

Numéro CAS:

19237-84-4

Poids moléculaire :

419.86

NACRES:

NA.77

PubChem Substance ID:

24277793

UNSPSC Code:

12352200

EC Number:

242-903-4

MDL number:

MFCD00058177

Beilstein/REAXYS Number:

4303561

Assay:

≥99.0% (HPLC)

Form:

powder

Quality level:

100

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Propriétés

Nom du produit

Prazosin hydrochloride, ≥99.0% (HPLC)

Quality Level

100

assay

≥99.0% (HPLC)

form

powder

solubility

H₂O: 0.5 mg/mL, methanol: 6 mg/mL, dilute aqueous acid: insoluble

SMILES string

Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4

InChI

1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H

InChI key

WFXFYZULCQKPIP-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Description

General description

Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.

Application

Prazosin hydrochloride has been used:

to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice
as an α1-adrenoceptor blocker,administered intragastrically in rats
as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions

Biochem/physiol Actions

Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.

Features and Benefits

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the α1-Adrenoceptors, α2-Adrenoceptors and Melatonin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Disclaimer

Hygroscopic; light sensitive.

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H336,H361fd,H373

pcodes

P202 - P260 - P271 - P280 - P304 + P340 + P312 - P308 + P313

Hazard Classifications

Repr. 2 - STOT RE 2 - STOT SE 3

target_organs

Central nervous system

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

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Contenu apparenté

Product Information Sheet - P7791

Product Information Sheet

Initial orthostatic hypotension and cerebral blood flow regulation: effect of α1-adrenoreceptor activity.

Nia C S Lewis et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 304(2), R147-R154 (2012-11-24)

We examined the hypothesis that α(1)-adrenergic blockade would lead to an inability to correct initial orthostatic hypotension (IOH) and cerebral hypoperfusion, leading to symptoms of presyncope. Twelve normotensive humans (aged 25 ± 1 yr; means ± SE) attempted to complete

Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord

Yu S Q and Wang D H

Acta Pharmacologica Sinica, 32(6), 845-845 (2011)

Haptoglobin reduces renal oxidative DNA and tissue damage during phenylhydrazine-induced hemolysis

Lim Y K, et al.

Kidney International, 58(3), 1033-1044 (2000)

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