S0802
Stearoyl coenzyme A lithium salt
≥90%
Synonyme(s) :
n-Octadecanoyl Coenzyme A
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A propos de cet article
Formule empirique (notation de Hill) :
C39H70N7O17P3S
Numéro CAS:
Poids moléculaire :
1034.00
NACRES:
NA.51
UNSPSC Code:
41106305
Assay:
≥90%
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Application
Coenzyme A functions as an acyl group carrier, acetyl-CoA. Stearoyl CoA is a saturated fatty acid metabolite involved in polyunsaturated fatty acid synthesis and the PPAR signaling pathway. Stearoyl CoA is used to study the specificity and kinetics of stearoyl-CoA desaturase(s) which lead to the formation of monounsaturated fatty acids.
Stearoyl coenzyme A lithium salt may be used as a substrate in the stearoyl-CoA desaturase assay in microsomes.
Biochem/physiol Actions
Stearoyl CoA is a saturated fatty acid metabolite involved in polyunsaturated fatty acid synthesis and the PPAR signaling pathway. Stearoyl CoA is a substrate for the enzyme stearoyl-CoA desaturase. Stearoyl CoA desaturation is the crucial step in unsaturated fatty acid biosynthesis. Stearoyl CoA is converted to oleoyl-CoA by stearoyl-CoA desaturase.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy
Roongta UV, et al.
Molecular Cancer Research, 9(11), 1551-1561 (2011)
R Ariel Igal
Carcinogenesis, 31(9), 1509-1515 (2010-07-03)
As part of a shift toward macromolecule production to support continuous cell proliferation, cancer cells coordinate the activation of lipid biosynthesis and the signaling networks that stimulate this process. A ubiquitous metabolic event in cancer is the constitutive activation of
The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
Miyazaki M, et al.
The Journal of Biological Chemistry, 275(39), 30132-30138 (2000)
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
Ntambi JM, et al.
Proceedings of the National Academy of Sciences of the USA, 99(17), 11482-11486 (2002)
M Minville-Walz et al.
Genes & nutrition, 7(2), 209-216 (2011-11-08)
Consumption of trans fatty acids is positively correlated with cardiovascular diseases and with atherogenic risk factors. Trans fatty acids might play their atherogenic effects through lipid metabolism alteration of vascular cells. Accumulation of lipids in vascular smooth muscle cells is
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