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Merck

S1076

SRC, active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyme(s) :

ASV, c-SRC, p60-Src

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A propos de cet article

NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
83-113 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in E. coli

Principaux documents

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Nom du produit

SRC, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

recombinant

expressed in E. coli

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

83-113 nmol/min·mg

mol wt

~83 kDa

UniProt accession no.

P12931

shipped in

dry ice

storage temp.

−70°C

Quality Level

200

Gene Information

human ... SRC(6714)

Application

SRC, active, GST tagged human has been used in the in vitro kinase assay.

Biochem/physiol Actions

SRC proto-oncogene, non-receptor tyrosine kinase (SRC) phosphorylates membrane proteins and nucleoproteins and activates various intracellular signaling cascades. It is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. In addition to increasing cell proliferation, a key role of SRC in cancer seems to be the ability to promote invasion and motility, functions that might contribute to tumor progression.

General description

SRC proto-oncogene, non-receptor tyrosine kinase (SRC) belongs to the family of non-receptor tyrosine kinases. SRC was originally identified as a transforming protein of the Rous sarcoma virus (RSV) that had enzymatic ability to phosphorylate tyrosine in protein substrates. It contains an amino-terminal domain, conserved Src-homology domains (SH2 and SH3), a tyrosine kinase domain and the carboxyl-terminus. The gene encoding this protein is localized on human chromosome 20q11.23.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Classe de stockage

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000391183
0000391183
SLCK8176
SLCG9683
SLCF1578

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin aIIb?3 to Initiate Outside-in Signaling in Platelets.
Wu Y
The Journal of Biological Chemistry, 290(25), 290(25)-290(25) (2015)
ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation.
Lievens PM
Molecular and Cellular Biology, 36(17), 2208-2225 (2016)
C Jacobs et al.
Cancer research, 43(4), 1696-1702 (1983-04-01)
An endogenous protein of human cells pp60c-src, which is closely related to the product of the transforming gene of Rous sarcoma virus, pp60v-src, has been quantitated by measuring its enzymatic activity in an immunoglobulin G protein kinase assay. The influence
Fangfang Chen et al.
American journal of cancer research, 8(8), 1466-1482 (2018-09-14)
R428 (BGB324) is an anti-cancer drug candidate under clinical investigation. It inhibits the receptor tyrosine kinase Axl and induces apoptosis of many types of cancer cells, but the relationship between the two has not been well established. We investigated the
Min Yu et al.
Microbiology and immunology, 65(1), 40-47 (2020-10-08)
The ischemia-reperfusion-induced damage in human brain microvascular endothelial cells (BMECs) is associated with disruption of the blood-brain barrier. CXC chemokine ligand 5 (CXCL5) is reported to be up-regulated in ischemic stroke. However, the detailed function of CXCL5 in this pathological
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