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Merck

S1141

Spermine tetrahydrochloride

BioReagent, Molecular Biology

Synonyme(s) :

N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :
C10H26N4 · 4HCl
Numéro CAS:
306-67-2
Poids moléculaire :
348.18
UNSPSC Code:
12352116
NACRES:
NA.52
PubChem Substance ID:
24899462
EC Number:
206-189-8
Beilstein/REAXYS Number:
3911771
MDL number:
MFCD00012914
Form:
solid
Quality level:
300

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InChI key

XLDKUDAXZWHPFH-UHFFFAOYSA-N

InChI

1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

SMILES string

Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN

grade

Molecular Biology

product line

BioReagent

form

solid

mp

310-311 °C (dec.) (lit.)

solubility

H2O: soluble 100 mg/mL, clear, colorless to light yellow

foreign activity

DNase, RNase, protease, NICKase, none detected

storage temp.

room temp

Quality Level

300

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General description

Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.

Application

Used to precipitate DNA from low salt aqueous buffers.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCM7828
BCCL7411
BCCK7695
BCCH9915
BCCG9744

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Consulter la Bibliothèque de documents

D C Allison et al.
Annals of surgery, 214(6), 648-656 (1991-12-01)
The DNA content of 47 adenocarcinomas arising in the head of the pancreas from patients who had undergone successful pancreatoduodenectomy was measured. The DNA measurements of each tumor were made without knowledge of the clinical course by absorption cytometry performed
Aracely A Lutes et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(24), 9910-9915 (2011-05-06)
Speciation in animals commonly involves an extrinsic barrier to genetic exchange followed by the accumulation of sufficient genetic variation to impede subsequent productive interbreeding. All-female species of whiptail lizards, which originated by interspecific hybridization between sexual progenitors, are an exception
Davis, L., et al.
Basic Methods in Molecular Biology, 120-120 (1986)
L L Vindeløv et al.
Cancer research, 40(11), 4295-4300 (1980-11-01)
Flow-cytometric DNA analysis yields information on ploidy and proliferative characteristics of a cell population. The analysis was implemented on small-cell anaplastic carcinoma of the lung using a rapid detergent technique for the preparation of fine-needle aspirates for DNA determination and
Binh V Vu et al.
PloS one, 7(12), e51863-e51863 (2013-01-04)
While most nucleic acids are intracellular, trace amounts of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), including micro RNAs, can also be found in peripheral blood. Many studies have suggested the potential utility of these circulating nucleic acids in prenatal
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