S7817
Scriptaid
synthetic (organic), ≥95%, Histone deacetylase inhibitor, solid
Synonyme(s) :
6-(1,3-Dioxo-1H, 3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide
Se connecter pour consulter les tarifs organisationnels et contractuels.
Sélectionner une taille de conditionnement
A propos de cet article
Formule empirique (notation de Hill) :
C18H18N2O4
Numéro CAS:
Poids moléculaire :
326.35
UNSPSC Code:
12352203
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Service technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aiderService technique
Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.
Laissez-nous vous aiderNom du produit
Scriptaid, ≥95%, solid
SMILES string
ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23
InChI key
JTDYUFSDZATMKU-UHFFFAOYSA-N
InChI
1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
biological source
synthetic (organic)
assay
≥95%
form
solid
mp
160-161 °C
solubility
DMSO:methanol (1:1): complete 2 mg/ml, clear, colorless to faintly yellow
DMSO: 1 mg/mL
methanol: soluble
storage temp.
−20°C
Quality Level
Catégories apparentées
Application
Scriptaid has been used in post activation of oocytes and embryo culture.
Scriptaid was used to enhance transcriptional activity in cloning procedures by somatic cell nuclear transfer.5,6
Biochem/physiol Actions
Histone deacetylase inhibitor with lower toxicity than trichostatin A.
Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.
Scriptaid inhibits the cell cycle progression of ovarian cancer cells by inducing arrest in G0/G1 and/or G2/M phase. Treatment of cells with scriptaid results in loss of mitochondrial membrane potential and increased acetylation of H3 and H4 histone tails.2 Sciptaid induces expression of γ-globin in human erythroid progenitors via p38 signaling and may be a treatment option for sickle cell disease.3 It enhances the transcriptional activity and protein expression in mouse embryos. This is useful in producing cloned, inbred mouse embryos that develop normally into adulthood with regular reproductive ability.4
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
General description
Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.
Legal Information
Sold under license of U.S. Patent No. 6,544,957.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Faites votre choix parmi les versions les plus récentes :
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity
Sharma V, et al.
Journal of Cellular and Molecular Medicine, 14(8), 2151-2161 (2010)
Kiho Lee et al.
Molecular reproduction and development, 80(2), 145-154 (2012-12-15)
In general, pig embryos established by somatic cell nuclear transfer (SCNT) are transferred at the one-cell stage because of suboptimal embryo culture conditions. Improvements in embryo culture can increase the practical application of late embryo transfer. The goal of this
Noriyuki Takai et al.
International journal of molecular medicine, 17(2), 323-329 (2006-01-05)
Histone deacetylase inhibitors (HDACIs) can inhibit cell proliferation, induce cell cycle arrest, and stimulate the apoptosis of cancer cells. We investigated the effects of a novel HDACI, Scriptaid, on the Ishikawa endometrial cancer cell line, SK-OV-3 ovarian cancer cell line
Nguyen Van Thuan et al.
Reproduction (Cambridge, England), 138(2), 309-317 (2009-05-13)
Since the birth of Cumulina, the first mouse clone produced by somatic cell nuclear transfer (SCNT), the success rate of cloning in mice has been extremely low compared with other species and most of the inbred mouse strains have never
Effects of combined treatment of MG132 and scriptaid on early and term development of porcine somatic cell nuclear transfer embryos
Mao J, et al.
Cellular Reprogramming, 14(5), 385-389 (2012)
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique