SAB1302240
ANTI-MOUSE NLRP6 (CENTER) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonyme(s) :
LRR and PYD domains-containing protein 6, NACHT, Nalp6, Nlrp6, Pypaf5
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A propos de cet article
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
7
Service technique
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rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
97402 Da
species reactivity
mouse
technique(s)
western blot: 1:1000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Nlrp6(101613)
General description
NLR family, pyrin domain containing 6 (NLRP6) maybe part of the inflammasome. It belongs to the Nod-like receptor family and is expressed in intestinal epithelial cells.
Biochem/physiol Actions
NLR family, pyrin domain containing 6 (NLRP6) has a role in innate immunity. It also maintains intestinal homeostasis by modulating autophagy and mucus secretion. Loss of NLRP6 has been shown to hinder the production of interleukin-18 (IL-18) and enhance susceptibility to epithelial-induced injury in rats.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Classe de stockage
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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NLRP6 Protects Il10-/- Mice from Colitis by Limiting Colonization of Akkermansia muciniphila.
Seregin SS
Cellular Reprogramming (2017)
Pierre-Gregoire Coulon et al.
Frontiers in immunology, 10, 1631-1631 (2019-08-02)
The crosstalk between the host's inflammasome system and the invading virulent/less-virulent viruses determines the outcome of the ensuing inflammatory response. An appropriate activation of inflammasomes triggers antiviral inflammatory responses that clear the virus and heal the inflamed tissue. However, an
NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury.
Seregin SS
Mucosal Immunology (2017)