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Merck

SAB4502981

Anti-Claudin 5, C-Terminal antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

CLD5, CLDN5, TMDVCF, Transmembrane protein deleted in VCFS

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A propos de cet article

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD03454913
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
26

Principaux documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 23 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

NCBI accession no.

O00501

UniProt accession no.

O00501

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CLDN5(7122)

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General description

Anti-Claudin 5 Antibody detects endogenous levels of total Claudin 5 protein.
The CLDN5 (claudins) gene is mapped to human chromosome 22q11.21 and codes for a transmembrane protein, which is a component of tight junction. The protein is a part of blood-brain barrier. The encoded protein is 303 - 218 amino acids long.

Immunogen

The antiserum was produced against synthesized peptide derived from human Claudin 5.

Immunogen Range: 169-218

Application

Anti-Claudin 5, C-Terminal antibody produced in rabbit has been used for intravascular perfusion labelling of vascular endothelial- cadherin and Immunofluorescence.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

Biochem/physiol Actions

The CLDN5 (claudins) gene encodes a component of tight junction and serves as a selective barrier for solutes and water. Upregulation of CLDN5 was observed in migraine. The expression of CLDN5 is reduced in lung squamous carcinoma. CLDN5 is known to increase p21 and decrease cyclin D1, leading to the retardation of cell cycle G1 to S transition. Cldn5 maintains homeostasis of the central nervous system, being a part of blood-brain barrier.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Classe de stockage

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
310145

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Molecular Architecture of the Blood Brain Barrier Tight Junction Proteins--A Synergistic Computational and In Vitro Approach.
Irudayanathan FJ
The Journal of Physical Chemistry B, 120(1), 77-88 (2016)
Claudin-5, -7, and -18 suppress proliferation mediated by inhibition of phosphorylation of Akt in human lung squamous cell carcinoma.
Akizuki R
Biochimica et Biophysica Acta, 1864(2), 293-302 (2017)
Polar and charged extracellular residues conserved among barrier-forming claudins contribute to tight junction strand formation.
Piontek A
Annals of the New York Academy of Sciences, 1397(1), 143-156 (2017)
Correlation between the radial peripapillary capillaries and the retinal nerve fibre layer in the normal human retina.
Yu PK
Experimental Eye Research, 129, 83-92 (2014)
B-acute lymphoblastic leukemia and cystinuria in a patient with duplication 22q11.21 detected by chromosomal microarray analysis.
Chang VY
Pediatric Blood & Cancer, 56(3), 470-473 (2011)
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