SML0330
S3I-201
≥97% (HPLC)
Synonyme(s) :
2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid, NSC 74859
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A propos de cet article
Formule empirique (notation de Hill) :
C16H15NO7S
Numéro CAS:
Poids moléculaire :
365.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
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S3I-201, ≥97% (HPLC)
InChI
1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
SMILES string
Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2
InChI key
HWNUSGNZBAISFM-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
Quality Level
Catégories apparentées
Application
S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:
- to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)
- to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines
- to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells
Biochem/physiol Actions
Inhibition of signal transducer and activator of transcription 3 (STAT3) activity by S3I-201 may be a potential therapeutic strategy for hypertensive kidney disease.
S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.
S3I-201 is a cell-permeable Stat3 inhibitor.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Kwang Bo Jung et al.
Nature communications, 9(1), 3039-3039 (2018-08-04)
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Safiye E Sarper et al.
Scientific reports, 8(1), 11208-11208 (2018-07-27)
Runx1 deficiency results in an anteriorly specific cleft palate at the boundary between the primary and secondary palates and in the first rugae area of the secondary palate in mice. However, the cellular and molecular pathogenesis underlying such regional specificity
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Chlorogenic acid (CA) is a phenolic compound purified from coffee, fruits and their associated beverages, which possess various biological properties, such as antioxidant and anticarcinogenic activities. The present study evaluated the effects of CA on lipopolysaccharide (LPS)‑induced inflammation in RAW264.7
Wei-Jan Wang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(2), 503-513 (2016-07-21)
Cisplatin (CDDP) is frequently used in combination chemotherapy with paclitaxel for treating urothelial carcinoma of the urinary bladder (UCUB). CDDP cross-resistance has been suggested to develop with paclitaxel, thus hindering successful UCUB treatment. Therefore, elucidating the mechanisms underlying CDDP-induced anticancer
Kwang Bo Jung et al.
Journal of clinical medicine, 8(7) (2019-07-07)
Human intestinal organoids (hIOs), which resemble the human intestine structurally and physiologically, have emerged as a new modality for the study of the molecular and cellular biology of the intestine in vitro. We recently developed an in vitro maturation technique
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