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SML1552

Tipiracil hydrochloride

Name: Tipiracil hydrochloride
Brand: SIGMA

≥98% (HPLC), thymidine phosphorylase inhibitor, powder

Synonyme(s) :

5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride, TPI hydrochloride

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A propos de cet article

Formule empirique (notation de Hill) :

C₉H₁₁ClN₄O₂ · HCl

Numéro CAS:

183204-72-0

Poids moléculaire :

279.12

UNSPSC Code:

12352200

PubChem Substance ID:

329825960

NACRES:

NA.77

MDL number:

MFCD01571384

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Propriétés

Nom du produit

Tipiracil hydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H₂O: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[H]Cl.ClC1=C(CN2C(CCC2)=N)NC(NC1=O)=O

InChI

1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H

InChI key

KGHYQYACJRXCAT-UHFFFAOYSA-N

Gene Information

human ... TYMP(1890)

Description

Biochem/physiol Actions

Tipiracil is an inhibitor of thymidine phosphorylase.

Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Preclinical investigation of potential use of thymidine phosphorylase-targeting tracer for diagnosis of nonalcoholic steatohepatitis.

Kei Higashikawa et al.

Nuclear medicine and biology, 82-83, 25-32 (2019-12-24)

Although liver biopsy is the gold standard for the diagnosis of nonalcoholic steatohepatitis (NASH), it has several problems including high invasiveness and sampling errors. Therefore, the development of alternative methods to overcome these disadvantages is strongly required. In this study

Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies.

Sumaira Javaid et al.

PloS one, 14(11), e0225056-e0225056 (2019-11-20)

Natural flora is the richest source of novel therapeutic agents due to their immense chemical diversity and novel biological properties. In this regard, eighteen natural products belonging to different chemical classes were evaluated for their thymidine phosphorylase (TP) inhibitory activity.