SML2083
[Ala13]-Apelin-13 trifluoroacetate salt
≥96% (HPLC)
Synonyme(s) :
(F13A)apelin-13, Alanine apelin-13, Apelin-13(F13A), Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Ala TFA, L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-alanine TFA, QRPRLSHKGPMPA TFA, [Ala-13] apelin-13
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A propos de cet article
Formule empirique (notation de Hill) :
C63H107N23O16S · xC2HF3O2
Numéro CAS:
Poids moléculaire :
1474.73 (free base basis)
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥96% (HPLC)
Form:
powder
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≥96% (HPLC)
form
powder
color
white to beige
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
(Ala13)-Apelin-13 corresponds to Apelin-13 with a Phe-to-Ala substitution at the C-terminus (F13A) and functions as an antagonist against apelin-dependent APJ functions both in cultures and in animal studies in vivo.
Apelin-13 with a Phe-to-Ala substitution at the C-terminus (F13A) and functions as an antagonist against apelin-dependent APJ functions.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Mehmet Bülbül et al.
American journal of physiology. Gastrointestinal and liver physiology, 310(4), G249-G261 (2015-12-19)
Apelin, an endogenous ligand for APJ receptor, has been reported to be upregulated in paraventricular nucleus (PVN) following stress. Central apelin is known to stimulate release of corticotropin-releasing factor (CRF) via APJ receptor. We tested the hypothesis that stress-induced gastrointestinal
Frédéric Adam et al.
Blood, 127(7), 908-920 (2015-12-05)
Apelin peptide and its receptor APJ are directly implicated in various physiological processes ranging from cardiovascular homeostasis to immune signaling. Here, we show that apelin is a key player in hemostasis with an ability to inhibit thrombin- and collagen-mediated platelet
Xue Han et al.
Atherosclerosis, 244, 1-8 (2015-11-19)
Vascular calcification (VC) is closely related to cardiovascular events in chronic kidney disease (CKD). Apelin has emerged as a potent regulator of cardiovascular function, but its role in VC during CKD remains unknown. We determined whether apelin plays a role