SRP0444
A20 human
recombinant, expressed in baculovirus infected Sf9 cells, ≥20% (SDS-PAGE)
Synonyme(s) :
OTU domain-containing protein 7C, OTUD7C, TNFAIP3, tumor necrosis factor-? induced protein 3
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A propos de cet article
NACRES:
NA.32
UNSPSC Code:
12352202
Form:
aqueous solution
Assay:
≥20% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells
Mol wt:
90.5 kDa
Service technique
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Laissez-nous vous aiderbiological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥20% (SDS-PAGE)
form
aqueous solution
mol wt
90.5 kDa
packaging
pkg of 50 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... TNFAIP3(7128)
General description
Human A20, also known as tumor necrosis factor-α induced protein 3 (TNFAIP3) or OTU domain-containing protein 7C (OTUD7C), (GenBank Accession No. NM_006290) amino acids 2-791(end) with an N-terminal FLAG-tag, MW=90.5 kDa, expressed in Sf9 insect cells via a Baculovirus expression system.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Classe de stockage
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Sarah G Hymowitz et al.
Nature reviews. Cancer, 10(5), 332-341 (2010-04-13)
Clinicians have suspected for hundreds of years that chronic activation of the immune system contributes to the development of cancer. However, the molecular mechanisms that mediate this precarious interplay are only now being elucidated. Recent reports have identified A20 as
Jing Liu et al.
Journal of biomedical science, 20, 74-74 (2013-10-09)
Intestinal polyps may further develop into colon cancer; the pathogenesis is not clear. The p53 gene is an important anti-cancer gene in the body, which is suppressed in cancer. The ubiquitin E3 ligase A20 (A20) plays a role in regulating
Chong-Shan Shi et al.
Autophagy, 6(7), 986-987 (2010-08-28)
Toll-like receptor 4 (TLR4) signaling triggers autophagy, which has been linked to both adaptive and innate immunity. Engagement of TLR4 recruits to the receptor complex Beclin 1, a key component of a class III phosphatidylinositol 3-kinase complex (PI3KC3) that initiates