T0910
Thioredoxin from Escherichia coli
recombinant, expressed in E. coli, essentially salt-free, lyophilized powder, ≥3 units/mg protein
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A propos de cet article
Form:
essentially salt-free, lyophilized powder
Assay:
≥90% (SDS-PAGE)
Biological source:
Escherichia coli
Recombinant:
expressed in E. coli
Mol wt:
11.7 kDa
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Laissez-nous vous aiderbiological source
Escherichia coli
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
essentially salt-free, lyophilized powder
specific activity
≥3 units/mg protein
mol wt
11.7 kDa
technique(s)
activity assay: suitable
solubility
water: 1.90-2.10 mg/mL, clear, colorless
Protein ID accession no.
UniProt accession no.
application(s)
cell analysis
storage temp.
−20°C
Quality Level
Gene Information
Escherichia coli K12 ... trxA(948289)
General description
Research area: Cell Signaling
Thioredoxin from Escherichia coli is a monomeric, globular protein. It has a central β-sheet surrounded by α-helices.
Thioredoxin from Escherichia coli is a monomeric, globular protein. It has a central β-sheet surrounded by α-helices.
Application
Thioredoxin from Escherichia coli has been used in thioredoxin reductase assay, peroxidase-coupled thioredoxin system assay and peroxiredoxin assay. It has also been used to study its effects on photoreceptor death in a mouse model of retinitis pigmentosa (RP) and its potential to modify retinal oxidative stress, glial changes, and vascular changes during the progression of the disease.
Biochem/physiol Actions
Mediates the reduction of disulfide bonds in proteins.
Thioredoxin from Escherichia coli catalyzes REDOX reactions and has a role in various biological processes. It modulates the structure and activity of many proteins. The enzyme thioredoxin reductase catalyzes the reduction of thioredoxin. Thioredoxin also has a role in oxidative stress response.Thioredoxin, known as both adult T cell leukemia-derived factor (ADF) and a cellular redox enzyme, functions as a cytokine or chemokine, facilitating cell-to-cell communication. Additionally, it plays a role in regulating cell growth and apoptosis.
Other Notes
GenBank® Accession Number M26133.
One unit will cause a ΔA650 of 1.0 in 1 min at 25 °C in the insulin reduction assay.
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis
Pramanik KC, et al.
Journal of Separation Science, 17(10), 1417-1432 (2012)
Thioredoxin Delays Photoreceptor Degeneration, Oxidative and Inflammation Alterations in Retinitis Pigmentosa
Gimeno-Hernandez R, et al.
Frontiers in Pharmacology, 11 (2020)
Thioredoxin Delays Photoreceptor Degeneration, Oxidative and Inflammation Alterations in Retinitis Pigmentosa
Hernandez RG, et al.
Frontiers in Pharmacology (2020)
Cell Signaling with Extracellular Thioredoxin and Thioredoxin-Like Proteins: Insight into Their Mechanisms of Action
Leveillard T and Ait-Ali N
Oxidative Medicine and Cellular Longevity (2017)
Thioredoxin from Escherichia coli as a Role Model of Molecular Recognition, Folding, Dynamics and Function.
Vazquez DS
Protein and peptide letters, 22(9), 801-815 (2015)
Contenu apparenté
Datasheet
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