T1019
(±)-Thiopental
Synonyme(s) :
5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid, Pentothal
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A propos de cet article
Formule empirique (notation de Hill) :
C11H18N2O2S
Numéro CAS:
Poids moléculaire :
242.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-984-3
MDL number:
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Laissez-nous vous aiderInChI key
IUJDSEJGGMCXSG-UHFFFAOYSA-N
InChI
1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
SMILES string
CCCC(C)C1(CC)C(=O)NC(=S)NC1=O
drug control
USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada
solubility
ethanol: complete 50 mg/mL
originator
Abbott
Quality Level
Gene Information
Catégories apparentées
Application
(±)-Thiopental was used to transiently anesthetize rats for in vivo NMR spectroscopy.
Biochem/physiol Actions
Thiopental is an anesthetic that decreases cerebral metabolic rate without altering the blood flow or oxygen consumption.
Features and Benefits
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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B M Jucker et al.
The Journal of biological chemistry, 272(16), 10464-10473 (1997-04-18)
The effects of increased plasma free fatty acids (FFA) on insulin-dependent whole body glucose disposal, skeletal muscle glycolysis, glycogen synthesis, pyruvate versus FFA/ketone oxidation, and glucose 6-phosphate (Glu-6-P) were investigated in the awake rat. A control group (glycerol-infused) and high
Cerebral circulation and metabolism during thiopental anesthesia and hyper-ventilation in man.
E C PIERCE et al.
The Journal of clinical investigation, 41, 1664-1671 (1962-08-01)
Colleen K Loo et al.
Journal of affective disorders, 142(1-3), 233-240 (2012-08-04)
Preliminary evidence suggests that the use of ketamine during electroconvulsive therapy (ECT) may be neuroprotective against cognitive impairment and have synergistic antidepressant effects. This study tested whether the addition of ketamine reduced cognitive impairment and enhanced efficacy over a course
Fong Huynh et al.
Therapeutic drug monitoring, 31(2), 153-169 (2009-01-30)
Thiopental is a barbiturate used in traumatic brain injuries (TBIs) to reduce intracranial pressure (ICP) and to manage cerebral ischemia. As thiopental follows Michaelis-Menten kinetics, therapeutic drug monitoring (TDM) has been used in practice to improve efficacy and reduce adverse
H Russo et al.
Clinical pharmacokinetics, 35(2), 95-134 (1998-09-18)
Thiopental is an ultra short-acting barbiturate which remains the standard against which other induction agents are judged; it is also indicated for the therapy of brain hypoxic-ischaemia injuries and status epilepticus. Aspects of drug distribution that govern the onset and
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