T8931
Thyrotropic hormone from bovine pituitary
Synonyme(s) :
TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands
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Laissez-nous vous aiderbiological source
bovine pituitary glands
form
powder
packaging
vial of 100 μg
technique(s)
cell culture | mammalian: suitable
storage temp.
2-8°C
Quality Level
Gene Information
cow ... TSHB(281552)
human ... TSHR(7253)
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Analysis Note
Contains phosphate buffer salts
Application
Thyrotropic hormone from bovine pituitary has been used:
- to induce cAMP production in orbital fibroblasts.
- as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.
- for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.
- for studying the thyrotropin involvement in photoperiodic signal transduction in mice.
Biochem/physiol Actions
Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function. In children, TSH plays a vital role in normal cognition and neurodevelopment. Circulating TSH is capable of binding to cell surface receptors in the thyroid gland. This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (131I) in individuals with thyroid cancer. It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
General description
Thyrotropin/thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family. This glycoprotein is produced by thyrotroph cells of the anterior pituitary gland. It circulates in free form and possess a short plasma half-life.
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy
Turcu AF, et al.
The Journal of Clinical Endocrinology and Metabolism, 98(5), 2153-2159 (2013)
Pituitary, Thyroid, and Parathyroid Pharmacology
Galasko GT
Pharmacology and Therapeutics for Dentistry, 417-428 (2017)
Roberto Rocchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(14), 6019-6024 (2007-03-29)
Bacterial infections and other pathologic conditions induce complex dysfunctions of the hypothalamic-pituitary-thyroid axis, collectively known as nonthyroidal illness (NTI). To explore the pathogenesis of bacterial NTI, we injected Mycobacterium tuberculosis extracts or Escherichia coli LPS in mice lacking key components
RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma
Lal G, et al.
Cancer, 107(12), 2752-2759 (2006)
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