V8261
(±)-Vigabatrin
Synonyme(s) :
(R,S)-4-Amino-5-hexenoic acid, (±)-γ-Vinyl-GABA, (±)-4-Aminohexenoic acid
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A propos de cet article
Formule empirique (notation de Hill) :
C6H11NO2
Numéro CAS:
Poids moléculaire :
129.16
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
270-929-6
MDL number:
Quality level:
Service technique
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originator
Lundbeck
SMILES string
NC(CCC(O)=O)C=C
InChI
1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)
InChI key
PJDFLNIOAUIZSL-UHFFFAOYSA-N
Gene Information
Biochem/physiol Actions
Irreversible GABA transaminase inhibitor. Increases intracellular concentration of GABA in nerve endings; possesses antiepileptic activity.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABA Transporters, GABAA Receptors and Glutamate/GABA Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Lundbeck. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
STOT RE 1
target_organs
Eyes,Central nervous system
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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R S Fisher
Brain research. Brain research reviews, 14(3), 245-278 (1989-07-01)
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Nicolas Froger et al.
Advances in experimental medicine and biology, 775, 69-83 (2013-02-09)
Retinal ganglion cells (RGCs) are spiking neurons, which send visual information to the brain, through the optic nerve. RGC degeneration occurs in retinal diseases, either as a primary process or secondary to photoreceptor loss. Mechanisms involved in this neuronal degeneration
Vigabatrin-related magnetic resonance imaging abnormalities in an infant with tuberous sclerosis complex and infantile spasms.
David T Hsieh et al.
The Journal of pediatrics, 162(1), 215-215 (2012-09-18)