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Merck

WH0003845M1

Anti-KRAS Antibody

mouse monoclonal, 3B10-2F2

Synonyme(s) :

KRAS Antibody - Monoclonal Anti-KRAS antibody produced in mouse, Kras Antibody, Anti-CKRAS, Anti-KIRAS, Anti-KRAS1, Anti-KRAS2, Anti-KRAS2A, Anti-KRAS2B, Anti-KRAS4A, Anti-KRAS4B, Anti-RASK2, Anti-v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

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A propos de cet article

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00239650
Conjugate:
unconjugated
Clone:
3B10-2F2, monoclonal
Application:
ELISA, ELISA (c), IF, WB
Citations:
62

Principaux documents

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Nom du produit

Monoclonal Anti-KRAS antibody produced in mouse, clone 3B10-2F2, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3B10-2F2, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

ELISA: suitable, capture ELISA: suitable, immunofluorescence: suitable, western blot: 1-5 μg/mL

isotype

IgG1κ

GenBank accession no.

BC013572

UniProt accession no.

P01116

application(s)

research pathology

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... KRAS(3845)

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Catégories apparentées

General description

Kirsten rat sarcoma viral oncogene homologue (KRAS) is an oncogene that is mapped to human chromosome 12p12.1. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. The gene codes for a member of the small GTPase superfamily.

Immunogen

KRAS (AAH13572, 1 a.a. ~ 188 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKKSKTKCVIM

Application

Monoclonal Anti-KRAS antibody produced in mouse has been used in immunoprecipitation, immunofluorescence, western blotting, indirect enzyme linked immunosorbent assay (ELISA).

Biochem/physiol Actions

Kirsten rat sarcoma viral oncogene homologue (KRAS) is a key protein of the Ras signaling pathways. It facilitates the invasion and metastasis of tumors. Gain-of-function mutations in the gene leads to the development of variety of tumors, including pancreatic, biliary tract and colon tumors. This mutation is rarely observed in gastric cancer.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Classe de stockage

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificats d'analyse (COA)

Lot/Batch Number
O3251-S2
NC141-S2
MB281-S2
L3221-S2
N4131-S2

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth
Mita H, et al.
BMC Cancer, 9, 1-16 (2009)
Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies
Waters AM, et al.
Science Signaling, 10, 84826-84826 (2017)
Frontiers in neurology and neuroscience research null
Eusebio Manchado et al.
Nature, 534(7609), 647-651 (2016-06-25)
Therapeutic targeting of KRAS-mutant lung adenocarcinoma represents a major goal of clinical oncology. KRAS itself has proved difficult to inhibit, and the effectiveness of agents that target key KRAS effectors has been thwarted by activation of compensatory or parallel pathways
MiR-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42
Wang YX, et al.
Oncotarget, 7, 84826-84826 (2016)
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