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Merck

Z103

Zolpidem

≥98% (HPLC), solid, benzodiazepine receptor agonist

Synonyme(s) :

N,N,6-Trimethyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine-3-acetamide

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A propos de cet article

Formule empirique (notation de Hill) :
C19H21N3O
Numéro CAS:
82626-48-0
Poids moléculaire :
307.39
UNSPSC Code:
12352200
PubChem Substance ID:
24902172
NACRES:
NA.77
MDL number:
MFCD00153885

Principaux documents

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Nom du produit

Zolpidem, ≥98% (HPLC), solid

SMILES string

CC1=CN2C(C=C1)=NC(C3=CC=C(C)C=C3)=C2CC(N(C)C)=O

InChI

1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3

InChI key

ZAFYATHCZYHLPB-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

drug control

USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
kontrollierte Droge in Deutschland

Quality Level

100

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRG2(2566)
rat ... Gabra1(29705), Gabra2(29706), Gabra5(29707), Tspo(24230)

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
DMSO: >10 mg/mL
ethanol: 50 mg/mL
methanol: 50 mg/mL
H2O: insoluble
dilute aqueous base: insoluble

originator

Sanofi Aventis

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Catégories apparentées

Biochem/physiol Actions

Potent and selective agonist for the benzodiazepine receptor associated with the GABAA receptor; hypnotic.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - STOT SE 3

target_organs

Central nervous system

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000319735
0000319736
0000319736
0000319735
0000173345

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Consulter la Bibliothèque de documents

Ming-May Lai et al.
Mayo Clinic proceedings, 89(5), 589-594 (2014-04-02)
To estimate the risk of head injury or fracture requiring hospitalization in patients treated with zolpidem. We identified 8188 patients 18 years and older who had received a first prescription for zolpidem between January 1, 2000, and December 31, 2009
Thomas Chao et al.
Drug and alcohol dependence, 185, 23-32 (2018-02-08)
Stress responding is linked to drug use, but little is known about stress responses in cannabis smokers. We investigated acute stress responding in cannabis smokers as a function of trauma exposure and sex, and relationships between stress responses and cannabis
Megan J Shram et al.
Journal of clinical psychopharmacology, 40(6), 568-578 (2020-10-22)
Human abuse potential studies include multiple measures to assess the subjective effects of central nervous system-active drugs. In this retrospective analysis, measurement properties of commonly used measures were assessed, and factor analysis was conducted to identify a core battery of
Sara C Mednick et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(10), 4494-4504 (2013-03-08)
An important function of sleep is the consolidation of memories, and features of sleep, such as rapid eye movement (REM) or sleep spindles, have been shown to correlate with improvements in discrete memory domains. Because of the methodological difficulties in
Hsin-I Shih et al.
Medicine, 94(17), e809-e809 (2015-05-02)
We evaluate the effects of zolpidem use to develop dementia or Alzheimer disease from the Taiwan National Health Insurance Research Database (NHIRD).A retrospective population-based nested case-control study. Newly diagnosed dementia patients 65 years and older and controls were sampled. A
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