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Merck

1279804

USP

Fluoxétine hydrochloride

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

(±)-N-Méthyl-γ-[4-(trifluorométhyl)phénoxy]benzènepropanamine hydrochloride, LY-110,140 hydrochloride, Prozac®

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A propos de cet article

Formule empirique (notation de Hill) :
C17H18F3NO · HCl
Numéro CAS:
56296-78-7
Poids moléculaire :
345.79
NACRES:
NA.24
PubChem Substance ID:
329749876
UNSPSC Code:
41116107
MDL number:
MFCD00214288

Principaux documents

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Nom du produit

Fluoxétine hydrochloride, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H

SMILES string

CNCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2.[H]Cl

InChI key

GIYXAJPCNFJEHY-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

fluoxetine

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... SLC6A4(6532)

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Catégories apparentées

Biochem/physiol Actions

Inhibiteur sélectif de la recapture de la sérotonine ; antidépresseur.

Legal Information

Vendu sous licence de Eli Lilly and Co.
Prozac is a registered trademark of Eli Lilly and Co.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Fluoxetine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Fluoxetine Tablets
  • Fluoxetine Delayed-Release Capsules
  • Olanzapine and Fluoxetine Capsules
  • Fluoxetine Oral Solution
  • Fluoxetine Capsules

Other Notes

Sales restrictions may apply.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - STOT RE 2 - STOT SE 3

target_organs

Central nervous system

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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R J Gonzalez-Rothi et al.
Chest, 107(6), 1763-1765 (1995-06-01)
We describe a patient who developed progressive dyspnea, lung infiltrates, and restrictive lung disease in association with the antidepressant fluoxetine hydrochloride (Prozac). The pathologic findings were consistent with hypersensitivity pneumonitis. An associated pulmonary phospholipidosis was also noted.
Paulina Jedynak et al.
Journal of psychiatric research, 56, 106-111 (2014-06-17)
The neurogenesis hypothesis of major depression has two main facets. One states that the illness results from decreased neurogenesis while the other claims that the very functioning of antidepressants depends on increased neurogenesis. In order to verify the latter, we
Sean C Godar et al.
Journal of psychiatric research, 56, 1-9 (2014-06-03)
The termination of serotonin (5-hydroxytryptamine, 5-HT) neurotransmission is regulated by its uptake by the 5-HT transporter (5-HTT), as well as its degradation by monoamine oxidase (MAO)-A. MAO-A deficiency results in a wide set of behavioral alterations, including perseverative behaviors and
Rody Kingston et al.
PLoS genetics, 17(11), e1009885-e1009885 (2021-11-05)
Molecular insights into the selective vulnerability of retinal ganglion cells (RGCs) in optic neuropathies and after ocular trauma can lead to the development of novel therapeutic strategies aimed at preserving RGCs. However, little is known about what molecular contexts determine
Melody V Wu et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(8), 1861-1871 (2014-02-13)
Adult hippocampal neurogenesis is critically implicated in rodent models of stress and anxiety as well as behavioral effects of antidepressants. Whereas similar factors such as psychiatric disorder and antidepressant administration are correlated with hippocampal volume in humans, the relationship between
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