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149101 1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem

149101
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₄H₇NO₂22059-21-8

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149101-250MGCN
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      Glass bottle 250 mg
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      Description
      OverviewAn agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks 3H-glycine binding to rat forebrain membrane (IC50 = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC50 = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.
      Catalogue Number149101
      Brand Family Calbiochem®
      SynonymsACPC
      References
      ReferencesViu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
      Zapata, A., et al. 1996. NeuroReport 7, 397.
      Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
      Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
      Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
      Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
      Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.
      Product Information
      CAS number22059-21-8
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₄H₇NO₂
      Chemical formulaC₄H₇NO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Application1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8, is an agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex.
      Biological Information
      Primary TargetGlycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex
      Primary Target IC<sub>50</sub>38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells
      Purity≥ 98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSGZ1110000
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      1-Aminocyclopropane-1-carboxylic Acid - CAS 22059-21-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      149101

      References

      Reference overview
      Viu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
      Zapata, A., et al. 1996. NeuroReport 7, 397.
      Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
      Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
      Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
      Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
      Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.

      Brochure

      Title
      Excitotoxic Glutamate Analogs Technical Bulletin
      Pathways and Biomarkers of Glutamatergic Synapse Flyer
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-April-2008 RFH
      SynonymsACPC
      DescriptionA potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks 3H-glycine binding to rat forebrain membranes (IC50 = 38 nM).
      FormCrystalline solid
      CAS number22059-21-8
      RTECSGZ1110000
      Chemical formulaC₄H₇NO₂
      Structure formulaStructure formula
      Purity≥ 98% by TLC
      SolubilityH₂O (40 mg/ml). May require heating and sonication to achieve complete solubilization.
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Irritant
      ReferencesViu, E., et al. 1998. J. Pharm. Exp. Ther. 285, 527.
      Zapata, A., et al. 1996. NeuroReport 7, 397.
      Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.
      Rottmann, W.H., et al. 1991. J. Mol. Biol. 222, 937.
      Marvizon, J.C., et al. 1989. J. Neurochem. 52, 992.
      Nadler, V., et al. 1988. Eur. J. Pharmacol. 157, 115.
      Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA 76, 170.