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118415 ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem

118415
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O

Pricing & Availability

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118415-60UGCN
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      Plastic ampoule 60 μg
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      Description
      OverviewAn amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration. Also acts as an inhibitor of NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Note: 1 set = 5 x 60 µg.
      Note: 1 set = 5 x 60 µg
      Catalogue Number118415
      Brand Family Calbiochem®
      SynonymsAdenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
      References
      ReferencesVispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
      Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
      Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
      Chemical formulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationADP-HPD, Dihydrate, Ammonium Salt, is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM).
      Biological Information
      Primary TargetPARG
      Primary Target IC<sub>50</sub>120 nM against poly(ADP-ribose) glycohydrolase (PARG)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      ADP-HPD, Dihydrate, Ammonium Salt - Calbiochem Certificates of Analysis

      TitleLot Number
      118415

      References

      Reference overview
      Vispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
      Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
      Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.

      Technical Info

      Title
      Technical Data Sheet - 118415 Envirocheck Contact plates VRB agar (Violet Red Bile Agar)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-October-2007 RFH
      SynonymsAdenosine 5ʹ-diphosphate (Hydroxymethyl)pyrrolidinediol, NH₄
      DescriptionAn amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (IC50 = 120 nM) vs. ADP-ribose (IC50 = 120 mM). Also inhibits NAD glycohydrolase from Bungarus fasciatus venom at much higher concentrations (IC50 = 260 µM). Does not affect the activities of either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A even at 1 mM concentration.
      FormWhite lyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅H₂₃N₆O₁₂P₂ · NH₄ · 2H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 week at -20°C.
      Toxicity Standard Handling
      ReferencesVispe, S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 9886.
      Slama, J.T., et al. 1995. J. Med. Chem. 38, 389.
      Slama, J.T., et al. 1995. J. Med. Chem. 38, 4332.