532586 AEBSF, HCl ≥99% by HPLC - CAS 30827-99-7 - Calbiochem

532586
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₈H₁₀FNO₂S·HCl30827-99-7

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      Glass bottle 250 mg
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      Description
      OverviewSpecific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K. A material with ≥97% purity by HPLC (Cat. No. 101500) & its InSolution™ is also available (Cat. No. 508436).

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number532586
      Brand Family Calbiochem®
      Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl, 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride, HCl
      References
      ReferencesCitron, M., et al. 1996. Neuron 17, 171.
      Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
      Mintz, G.R. 1993. BioPharm. 6, 34.
      Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
      Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
      Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
      Baker, B.R., and Cory, M. 1971. 14, 119.
      Product Information
      CAS number30827-99-7
      FormWhite powder
      Hill FormulaC₈H₁₀FNO₂S·HCl
      Chemical formulaC₈H₁₀FNO₂S·HCl
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSerine proteases
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 34

      Causes burns.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Corrosive
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AEBSF, HCl ≥99% by HPLC - CAS 30827-99-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Citron, M., et al. 1996. Neuron 17, 171.
      Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
      Mintz, G.R. 1993. BioPharm. 6, 34.
      Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
      Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
      Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
      Baker, B.R., and Cory, M. 1971. 14, 119.

      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature
      New Products - Antibodies, Small Molecule, Inhibitors (MM)

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-December-2014 JSW
      Synonyms4-(2-Aminoethyl)benzenesulfonylfluoride, HCl, 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride, HCl
      DescriptionSpecific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332) and DFP (Cat. No. 30967). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K. A material with ≥97% purity by HPLC (Cat. No. 101500) & its InSolution™ is also available (Cat. No. 508436).
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number30827-99-7
      Chemical formulaC₈H₁₀FNO₂S·HCl
      Purity≥99% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage +2°C to +8°C
      Protect from moisture
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Corrosive
      ReferencesCitron, M., et al. 1996. Neuron 17, 171.
      Ohkubo, I., et al. 1994. J. Biochem. 116, 1182.
      Mintz, G.R. 1993. BioPharm. 6, 34.
      Lawson, W.B., et al. 1982. Folia Haematol. 109, 52.
      Markwardt, F., et al. 1974. Biochem. Pharmacol. 23, 2247.
      Markwardt, F., et al. 1973. Thromb. Res. 2, 343.
      Baker, B.R., and Cory, M. 1971. 14, 119.