658403 AG 538 - CAS 133550-18-2 - Calbiochem

658403
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₆H₁N₁₁O₅133550-18-2

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658403-5MGCN
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      Plastic ampoule 5 mg
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      Description
      OverviewA potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC50 = 400 nM). Reaction is competitive with respect to IGF-1R substrate. Also inhibits the phosphorylation of PTK substrate poly(Glu,Tyr) by IGF-1R, IR, EGF-R, and Src (IC50 = 60 nM, 113 nM, 370 nM, and 2.4 µM, respectively). Inhibits the phosphorylation of PKB at a much higher concentration (IC50 = 76 µM).
      Catalogue Number658403
      Brand Family Calbiochem®
      Synonymsα-Cyano-(3,4-dihydroxy)cinnamoyl-(3ʹ,4ʹ-dihydroxyphenyl)ketone, Tyrphostin AG 538
      References
      ReferencesBlum, G., et al. 2000. Biochemistry 39, 15705.
      Product Information
      CAS number133550-18-2
      ATP CompetitiveY
      FormDark orange to brown solid
      Hill FormulaC₁₆H₁N₁₁O₅
      Chemical formulaC₁₆H₁N₁₁O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIGF-1 receptor kinase
      Primary Target IC<sub>50</sub>400 nM against IGF-1 receptor kinase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AG 538 - CAS 133550-18-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      658403

      References

      Reference overview
      Blum, G., et al. 2000. Biochemistry 39, 15705.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2016 JSW
      Synonymsα-Cyano-(3,4-dihydroxy)cinnamoyl-(3ʹ,4ʹ-dihydroxyphenyl)ketone, Tyrphostin AG 538
      DescriptionA potent, cell-premeable, reversible, and competitive inhibitor of IGF-1R (insulin-like growth factor-1 receptor) kinase autophosphorylation (IC50 = 400 nM). Also inhibits the phosphorylation of PTK substrate poly (Glu,Tyr) by IGF-1R, IR, EGF-R, and Src (IC50 = 60 nM, 113 nM, and 2.4 µM respectively). Inhibits the phosphorylation of PKB at a much higher concentration (IC50 = 76 µM). Inhibition is competitive with respect to the substrate binding site of IGF-1R kinase. Also inhibits the authophosphorylation of IGF-1R and the activation of PKB and ERK2 in NIH-3T3 cells over-expressing IGF-1R.
      FormDark orange to brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number133550-18-2
      Chemical formulaC₁₆H₁N₁₁O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBlum, G., et al. 2000. Biochemistry 39, 15705.