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208719 ALLN - CAS 110044-82-1 - Calbiochem

208719
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₂₀H₃₇N₃O₄110044-82-1

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208719-25MGCN
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      Plastic ampoule 25 mg
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      Description
      OverviewCell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Modulates the processing of the β-amyloid precursor protein (βAPP) to β-amyloid (Aβ). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also inhibits reovirus-induced apoptosis in L929 cells. Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208750) in DMSO is also available.
      Catalogue Number208719
      Brand Family Calbiochem®
      SynonymsLLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
      References
      ReferencesDebiasi, R.L., et al. 1999. J. Virol. 73, 695.
      Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
      Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
      Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
      Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
      Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
      Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
      Product Information
      CAS number110044-82-1
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₀H₃₇N₃O₄
      Chemical formulaC₂₀H₃₇N₃O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
      Biological Information
      Primary TargetCalpain-1
      Primary Target K<sub>i</sub>190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceN-Acetyl-Leu-Leu-Nle-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ALLN - CAS 110044-82-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      ALLN - CAS 110044-82-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      208719

      References

      Reference overview
      Debiasi, R.L., et al. 1999. J. Virol. 73, 695.
      Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
      Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
      Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
      Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
      Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
      Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Proteasomes Technical Bulletin

      Citations

      Title
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-October-2007 RFH
      SynonymsLLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
      DescriptionInhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and proteasome (Ki = 6 µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex.
      FormWhite to off-white solid
      CAS number110044-82-1
      Chemical formulaC₂₀H₃₇N₃O₄
      Peptide SequenceN-Acetyl-Leu-Leu-Nle-CHO
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesDebiasi, R.L., et al. 1999. J. Virol. 73, 695.
      Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
      Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
      Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
      Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
      Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
      Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
      Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
      Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
      Citation
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.