Millipore Sigma Vibrant Logo

28745 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem

This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Dibutyryl-cAMP, Na

Primary Target: PKA
View Products on Sigmaaldrich.com
28745
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
16980-89-5C₁₈H₂₃N₅O₈P · Na

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
28745-100MGCN
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 100 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      28745-25MGCN
      Retrieving availability...
      —
      Limited Availability Limited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Plastic ampoule 25 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          Description
          OverviewA cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
          Catalogue Number28745
          Brand Family Calbiochem®
          SynonymsDibutyryl-cAMP, Na
          References
          ReferencesNoveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
          Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
          Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
          Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
          Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
          Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
          Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
          Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
          Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.
          Product Information
          CAS number16980-89-5
          ATP CompetitiveN
          FormWhite lyophilized solid
          Hill FormulaC₁₈H₂₃N₅O₈P · Na
          Chemical formulaC₁₈H₂₃N₅O₈P · Na
          HS Code2933 59 99
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Applications
          Biological Information
          Primary TargetPKA
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSES5055500
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions are stable for up to 3 days at 4°C or for up to 3 months at -20°C. Avoid pH >8.5.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          28745-100MGCN 04055977197839
          28745-25MGCN 04055977090970

          Documentation

          Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem Certificates of Analysis

          TitleLot Number
          28745

          References

          Reference overview
          Noveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
          Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
          Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
          Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
          Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
          Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
          Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
          Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
          Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-March-2008 JSW
          SynonymsDibutyryl-cAMP, Na
          DescriptionCell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Known to cause an increase in the steady state level of the parathyroid hormone related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
          FormWhite lyophilized solid
          CAS number16980-89-5
          RTECSES5055500
          Chemical formulaC₁₈H₂₃N₅O₈P · Na
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions are stable for up to 3 days at 4°C or for up to 3 months at -20°C. Avoid pH >8.5.
          Toxicity Standard Handling
          ReferencesNoveen, A., et al. 1996. Biochem. Biophys. Res. Commun. 219, 180.
          Tsai, C.H., et al. 1995. J. Cell. Physiol. 164, 108.
          Leszczynski, D., et al. 1994. Am. J. Pathol. 145, 1265.
          Miller, C., et al. 1994. J. Neurosci. Res. 38, 56.
          Hinko, A., and Soloff, M.S. 1993. Endocrinology 132, 126.
          Ikeda, K., et al. 1993. J. Biol. Chem. 268, 1174.
          Park, E.A., et al. 1993. J. Biol. Chem. 268, 613.
          Hei, Y-J., et al. 1991. Mol. Pharmacol. 39, 233.
          Posternak, T., and Weimann, G. 1974. Methods Enzymol. 38, 399.