124020 Sigma-AldrichAkt Inhibitor X - CAS 925681-41-0 - Calbiochem
Akt Inhibitor X, CAS 925681-41-0, is a cell-permeable, reversible & selective inhibitor of Akt phosphorylation and its in vitro kinase activity. Has minimal effect on PI 3-K, PDK1, or SGK1.
More>> Akt Inhibitor X, CAS 925681-41-0, is a cell-permeable, reversible & selective inhibitor of Akt phosphorylation and its in vitro kinase activity. Has minimal effect on PI 3-K, PDK1, or SGK1. Less<<Synonyms: 10-DEBC HC, 10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-NCP
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Overview
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Key Spec Table
CAS # | Empirical Formula |
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925681-41-0 | C₂₀H₂₅ClN₂O • HCl |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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124020-5MGCN |
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Plastic ampoule | 5 mg |
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Description | |
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Overview | A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. Also available as a 20 mM solution in H2O(Cat. No. 124039). |
Catalogue Number | 124020 |
Brand Family | Calbiochem® |
Synonyms | 10-DEBC HC, 10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-NCP |
References | |
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References | Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press. Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924. |
Product Information | |
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CAS number | 925681-41-0 |
ATP Competitive | N |
Form | White solid |
Hill Formula | C₂₀H₂₅ClN₂O • HCl |
Chemical formula | C₂₀H₂₅ClN₂O • HCl |
Hygroscopic | Hygroscopic |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Physicochemical Information | |
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Cell permeable | Y |
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Packaged under inert gas | Packaged under inert gas |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
124020-5MGCN | 04055977205749 |
Documentation
Akt Inhibitor X - CAS 925681-41-0 - Calbiochem Certificates of Analysis
Title | Lot Number |
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124020 |
References
Reference overview |
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Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press. Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924. |
Brochure
Title |
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Akt |