175580 Sigma-AldrichAngiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem
The Angiogenesis Inhibitor, also referenced under CAS 186611-44-9, controls the biological activity of Angiogenesis. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The Angiogenesis Inhibitor, also referenced under CAS 186611-44-9, controls the biological activity of Angiogenesis. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<Synonyms: (Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one
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Overview
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Key Spec Table
CAS # | Empirical Formula |
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186611-44-9 | C₁₂H₉N₃O |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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175580-10MGCN |
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Plastic ampoule | 10 mg |
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Description | |
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Overview | A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM). |
Catalogue Number | 175580 |
Brand Family | Calbiochem® |
Synonyms | (Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one |
References | |
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References | Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243. |
Product Information | |
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CAS number | 186611-44-9 |
ATP Competitive | Y |
Form | Yellow solid |
Hill Formula | C₁₂H₉N₃O |
Chemical formula | C₁₂H₉N₃O |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | hEGF-R tyrosine kinase activity |
Primary Target IC<sub>50</sub> | 54% inhibition at 10 µM against hEGF-R tyrosine kinase activity |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
175580-10MGCN | 04055977222920 |
Documentation
Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem SDS
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Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem Certificates of Analysis
Title | Lot Number |
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175580 |
References
Reference overview |
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Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243. |