616371 Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - CAS 9087-70-1 - Calbiochem

616371
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₈₄H₄₃₂N₈₄O₇₉S₇9087-70-1

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616371-5MGCN
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      Plastic ampoule 5 mg
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      Description
      OverviewRecombinant, bovine aprotinin supplied without animal-derived components. Aprotinin is a competitive, reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful for protein purification and for extending the life of cells in culture by preventing proteolytic damage.
      Catalogue Number616371
      Brand Family Calbiochem®
      SynonymsPancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor, Kallikrein-Trypsin Inactivator, Antikrein, Basic Pancreatic Trypsin Inhibitor
      References
      ReferencesDeutscher, M.P., 1990. Methods Enzymol. 182, 83.
      Product Information
      CAS number9087-70-1
      Unit of DefinitionOne TIU (Trypsin Inhibitory Unit) is defined as the amount of aprotinin or product or inhibitor that will decrease the activity of 2 trypsin units by 50% where one trypsin unit will hydrolyze 1 µmol BAPNA per min at 25°C, pH 7.8.
      ATP CompetitiveN
      EC number2329949
      FormWhite to yellow powder
      FormulationContains no animal-derived components.
      Hill FormulaC₂₈₄H₄₃₂N₈₄O₇₉S₇
      Chemical formulaC₂₈₄H₄₃₂N₈₄O₇₉S₇
      ReversibleY
      Quality LevelMQ200
      Applications
      Biological Information
      Primary Targetchymotrypsin
      Primary Target IC<sub>50</sub>Kd = 5 x 10-14 M, 2.3 x 10-10 M, 1 x 10-7 M against trypsin, plasmin, and kallikrein, respectively
      Purity≥95% by SDS-PAGE
      Specific Activity>5 TIU/mg protein
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYN5080000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - CAS 9087-70-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      616371

      References

      Reference overview
      Deutscher, M.P., 1990. Methods Enzymol. 182, 83.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2016 JSW
      SynonymsPancreatic Trypsin Inhibitor, Trypsin-Kallikrein Inhibitor, Kallikrein-Trypsin Inactivator, Antikrein, Basic Pancreatic Trypsin Inhibitor
      DescriptionRecombinant, bovine aprotinin supplied without animal-derived components. Aprotinin is a competitive, reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful for protein purification and for extending the life of cells in culture by preventing proteolytic damage.
      FormWhite to yellow powder
      FormulationContains no animal-derived components.
      Concentration Label Please refer to vial label for lot-specific concentration
      CAS number9087-70-1
      RTECSYN5080000
      EC number2329949
      Chemical formulaC₂₈₄H₄₃₂N₈₄O₇₉S₇
      Purity≥95% by SDS-PAGE
      Specific activity>5 TIU/mg protein
      Unit definitionOne TIU (Trypsin Inhibitory Unit) is defined as the amount of aprotinin or product or inhibitor that will decrease the activity of 2 trypsin units by 50% where one trypsin unit will hydrolyze 1 µmol BAPNA per min at 25°C, pH 7.8.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Toxicity Standard Handling
      Merck USA index14, 757
      ReferencesDeutscher, M.P., 1990. Methods Enzymol. 182, 83.