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196000 Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem

196000
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₃₅H₅₈O₉88899-55-2

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196000-1SETCN
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      Description
      OverviewA macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution™ format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).
      Note: 1 set = 3 x 10 µg
      Catalogue Number196000
      Brand Family Calbiochem®
      References
      ReferencesSinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
      Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
      Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
      Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
      Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
      Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
      Drose, S., et al. 1993. Biochemistry 32, 3902.
      Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
      Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.
      Product Information
      CAS number88899-55-2
      FormWhite solid
      Hill FormulaC₃₅H₅₈O₉
      Chemical formulaC₃₅H₅₈O₉
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetvacuolar type H+ ATPase
      Primary Target IC<sub>50</sub>500 pM
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      196000

      References

      Reference overview
      Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
      Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
      Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
      Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
      Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
      Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
      Drose, S., et al. 1993. Biochemistry 32, 3902.
      Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
      Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-February-2010 JSW
      DescriptionA macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 0.5 nM) and is a valuable tool for distinguishing among different types of ATPases. Reported to selectivity inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). Blocks lysosomal cholesterol trafficking in macrophages. Known to interfere with pH regulation in brain cells. Inhibits bone resorption both in vivo and in vitro. Has been shown to exhibit cytotoxic effects on a number of cell lines in a cell viability assay.
      FormWhite solid
      CAS number88899-55-2
      Chemical formulaC₃₅H₅₈O₉
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (100 µM) or Ethanol
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesSinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
      Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
      Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
      Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
      Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
      Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
      Drose, S., et al. 1993. Biochemistry 32, 3902.
      Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
      Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.