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SCT090 BioTracker Bacterial FtsZ Live Cell Dye

Fluorescence probe for detecting FtsZ in bacteria.

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SCT090
1 mg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCT090
      DescriptionBioTracker Bacterial FtsZ Live Cell Dye
      OverviewThe filamentous temperature-sensitive Z (FtsZ) protein is a promising target for the development of new antibacterial drug targets. FtsZ is a protein encoded by the ftsZ gene that assembles into a ring at the future site of bacterial cell division and is one of the most conserved proteins in prokaryotes. This live cell probe will aid development of new FtsZ inhibitors and enable screening for FtsZ inhibition in a broad range of bacterial species.

      BioTracker Bacterial FtsZ Live Cell Dye is a BODIPY conjugated fluorescent probe that binds FtsZ proteins from both Gram-positive pathogens (Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Streptococcus pyogenes, Streptococcus agalactiae, and Streptococcus pneumoniae) and Gram-negative pathogens (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii) (1). It allows for visualization of FtsZ using fluorescence microscopy, and can be used to monitor and identify non-fluorescent FtsZ inhibitors in these target pathogens.

      Spectral Properties
      Excitation: 488 nm
      Emission: 510 nm

      Reference:
      1. Ferrer-González, Edgar, et al. "Structure-Guided Design of a fluorescent probe for the Visualization of ftsZ in clinically important Gram-positive and Gram-negative Bacterial pathogens." Scientific reports 9.1 (2019): 1-16.
      Alternate Names
      • Live Cell Imaging Probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized. Red solid.
      Applications
      ApplicationFluorescence probe for detecting FtsZ in bacteria.
      Biological Information
      Molecular Weight782.1
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C, desiccate and protect from light.
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCT090 04065265944502