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203291 Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem

203291
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₂₅H₂₄N₄O₂ · HCl176504-36-2

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203291-1MGCN
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      Description
      OverviewAn enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290). A reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). May inhibit protein kinase A at much higher concentrations (Ki = 2 µM).
      Catalogue Number203291
      Brand Family Calbiochem®
      Synonyms2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
      References
      ReferencesLe Panse, R., et al. 1994. Mol. Pharmacol. 46, 445.
      Kuchera, S., et al. 1993. Agents Actions 39, C169.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
      Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
      Product Information
      CAS number176504-36-2
      ATP CompetitiveY
      FormOrange-red solid
      Hill FormulaC₂₅H₂₄N₄O₂ · HCl
      Chemical formulaC₂₅H₂₄N₄O₂ · HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetProtein kinase C
      Primary Target K<sub>i</sub>10 nM against protein kinase C
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      203291

      References

      Reference overview
      Le Panse, R., et al. 1994. Mol. Pharmacol. 46, 445.
      Kuchera, S., et al. 1993. Agents Actions 39, C169.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
      Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

      Citations

      Title
    • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
    • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-January-2010 RFH
      Synonyms2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
      DescriptionA reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). Inhibits protein kinase A at much higher concentrations (Ki = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).
      FormOrange-red solid
      CAS number176504-36-2
      Chemical formulaC₂₅H₂₄N₄O₂ · HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml) or H₂O (10 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Toxicity Standard Handling
      ReferencesLe Panse, R., et al. 1994. Mol. Pharmacol. 46, 445.
      Kuchera, S., et al. 1993. Agents Actions 39, C169.
      Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
      Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
      Citation
    • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
    • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.