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236603 C-Reactive Protein, Human Serum, High Purity

236603
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236603-100UGCN
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      Glass bottle 100 μg
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      Description
      OverviewNative C-reactive protein highly purified from human serum. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer. Intended for use as a calibration standard for assays of CRP, for structural and functional studies, and as an antigen for production of antisera. Calibrated by electroimmunoassay against WHO reference standard or equivalent.
      M.W. 23,000 (monomer); 115,000 (pentamer).
      No reaction in ODD and Laurell electroimmunoassay against polyvalent antiserum to normal human serum, antiserum to pooled effusion fluids and monospecific antiserum to human IgG.
      Catalogue Number236603
      Brand Family Calbiochem®
      SynonymsCRP
      References
      ReferencesPaffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.
      Product Information
      CAS number9007-41-4
      FormLiquid
      FormulationIn 140 mM NaCl, 10 mM Tris, 2 mM CaCl₂, 0.1% NaN₃, pH 8.0.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by SDS-PAGE
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      C-Reactive Protein, Human Serum, High Purity SDS

      Title

      Safety Data Sheet (SDS) 

      C-Reactive Protein, Human Serum, High Purity Certificates of Analysis

      TitleLot Number
      236603

      References

      Reference overview
      Paffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.

      Citations

      Title
    • Paramita Baruah, et al. (2006) The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells and edits the cross-presentation of self, viral and tumor antigens. Blood 107, 151-158.
    • Elaine Paffen, Hans L. Vos and Rogier M. Bertina. (2004) C-Reactive Protein Does Not Directly Induce Tissue Factor in Human Monocytes. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 975-981.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-September-2007 RFH
      SynonymsCRP
      DescriptionNative C-reactive protein highly purified from human serum. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer. Intended for use as a calibration standard for assays of CRP, for structural and functional studies, and as an antigen for production of antisera. Calibrated by electroimmunoassay against WHO reference standard or equivalent.
      FormLiquid
      FormulationIn 140 mM NaCl, 10 mM Tris, 2 mM CaCl₂, 0.1% NaN₃, pH 8.0.
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      CAS number9007-41-4
      Purity≥99% by SDS-PAGE
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      Merck USA index14, 2603
      ReferencesPaffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.
      Citation
    • Paramita Baruah, et al. (2006) The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells and edits the cross-presentation of self, viral and tumor antigens. Blood 107, 151-158.
    • Elaine Paffen, Hans L. Vos and Rogier M. Bertina. (2004) C-Reactive Protein Does Not Directly Induce Tissue Factor in Human Monocytes. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 975-981.