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219502 Cathepsin L Inhibitor, CAA0225 - Calbiochem

219502
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₈H₂₉N₃O₅

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219502-1MGCN
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      Description
      OverviewAn epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.
      Catalogue Number219502
      Brand Family Calbiochem®
      References
      ReferencesTakahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
      Ueno, T., et al. 2009. Autophagy 5, 878.
      Product Information
      FormWhite solid
      Hill FormulaC₂₈H₂₉N₃O₅
      Chemical formulaC₂₈H₂₉N₃O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥ 95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cathepsin L Inhibitor, CAA0225 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cathepsin L Inhibitor, CAA0225 - Calbiochem Certificates of Analysis

      TitleLot Number
      219502

      References

      Reference overview
      Takahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
      Ueno, T., et al. 2009. Autophagy 5, 878.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-March-2011 RFH
      DescriptionAn epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.
      FormWhite solid
      Chemical formulaC₂₈H₂₉N₃O₅
      Structure formulaStructure formula
      Purity≥ 95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTakahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
      Ueno, T., et al. 2009. Autophagy 5, 878.