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238803 Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem

238803
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₀H₂₈N₆O₃199986-75-9

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238803-5MGCN
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 = ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
      Catalogue Number238803
      Brand Family Calbiochem®
      Synonyms2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
      References
      ReferencesBhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
      Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
      Product Information
      CAS number199986-75-9
      ATP CompetitiveY
      DeclarationSold under license of U.S. Patents 6,617,331 and 6,803,371.
      FormWhite to off-white solid
      Hill FormulaC₂₀H₂₈N₆O₃
      Chemical formulaC₂₀H₂₈N₆O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk2/A, Cdk2/E
      Primary Target IC<sub>50</sub>0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      238803

      References

      Reference overview
      Bhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
      Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-October-2020 JSW
      Synonyms2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
      DescriptionA cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number199986-75-9
      Chemical formulaC₂₀H₂₈N₆O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesBhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
      Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.