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238811 Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem

238811
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₉H₁₀N₆O140651-18-9

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238811-5MGCN
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      Description
      OverviewA cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC50 = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC50 = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines.
      Catalogue Number238811
      Brand Family Calbiochem®
      Synonyms4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol
      References
      ReferencesKrystof, V., et al. 2006. J. Med. Chem. 49, 6500.
      Product Information
      CAS number140651-18-9
      ATP CompetitiveY
      FormOrange solid
      Hill FormulaC₉H₁₀N₆O
      Chemical formulaC₉H₁₀N₆O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk9
      Primary Target IC<sub>50</sub>350 nM, using Cdk9/T1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      238811

      References

      Reference overview
      Krystof, V., et al. 2006. J. Med. Chem. 49, 6500.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-August-2007 JSW
      Synonyms4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol
      DescriptionA cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC50 = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC50 = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number140651-18-9
      Chemical formulaC₉H₁₀N₆O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesKrystof, V., et al. 2006. J. Med. Chem. 49, 6500.