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509583 Diaphanous (mDia)-related Formin Agonist, IMM01 - CAS 218795-74-5

An agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction (IC₅₀ = 140 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Formin Activator

Primary Target: mDia
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509583
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
218795-74-5C₁₂H₁₇N₃O₂S

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      Description
      OverviewA hydrazinecarbothioamide derived intramimic that acts as an agonist of mammalian Diaphanous (mDia)-related formins and disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction (IC50 = 140 nM). Shown to trigger actin assembly and stabilize microtubules in a dose -dependent manner and at levels similar to those induced by Taxol. Induces caspase-3 activation and apoptosis in NIH 3T3 and SW480 cells(~ 100 µM) and slows the growth of SW480 xenograft tumors in mice (~ 25 mg/kg). Shown to induce LacZ expression, producing b-gal activity that is comparable to effects seen with cytochalasin D treatment.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number509583
      Brand Family Calbiochem®
      SynonymsFormin Activator
      References
      ReferencesLash, L.L., et al. 2013. Cancer Res.73, 6793.
      Copeland, S.J. et al. 2007. J Biol. Chem. 282, 30120.
      Product Information
      CAS number218795-74-5
      FormOff-white powder
      Hill FormulaC₁₂H₁₇N₃O₂S
      Chemical formulaC₁₂H₁₇N₃O₂S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmDia
      Primary Target IC<sub>50</sub>140 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.09583.0001 04055977240962

      Documentation

      Diaphanous (mDia)-related Formin Agonist, IMM01 - CAS 218795-74-5 SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Lash, L.L., et al. 2013. Cancer Res.73, 6793.
      Copeland, S.J. et al. 2007. J Biol. Chem. 282, 30120.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-March-2014 JSW
      SynonymsFormin Activator
      DescriptionA hydrazinecarbothioamide derived intramimic that acts as an agonist of mammalian Diaphanous (mDia)-related formins and disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction (IC50 = 140 nM). Shown to trigger actin assembly and stabilize microtubules in a dose -dependent manner and at levels similar to those induced by Taxol. Induces caspase-3 activation and apoptosis in NIH 3T3 and SW480 cells(~ 100 µM) and slows the growth of SW480 xenograft tumors in mice (~ 25 mg/kg). Shown to induce LacZ expression, producing b-gal activity that is comparable to effects seen with cytochalasin D treatment.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number218795-74-5
      Chemical formulaC₁₂H₁₇N₃O₂S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLash, L.L., et al. 2013. Cancer Res.73, 6793.
      Copeland, S.J. et al. 2007. J Biol. Chem. 282, 30120.